Results 21 to 30 of about 7,407 (178)

Study of cutaneous leishmaniasis in the State of Campeche (Yucatan Peninsula), Mexico, over a period of two year

Salud Pública de México, 2015
Objective. To study cutaneous leishmaniasis (CL), in the Calakmul municipality of the Campeche State, during two years. Materials and methods. Individuals with skin lesions were evaluated. Aspirates taken from the lesions were cultured, PCR was performed
Mirsha Pamela Hernández-Rivera, Omar Hernández-Montes, Adelaido Chiñas-Pérez, Juan Miguel Batiza-Avelar, Gustavo Sánchez-Tejeda, Carlos Wong-Ramírez, Amalia Monroy-Ostria   +6 more
doaj   +1 more source

Leishmania (Leishmania) mexicana en el corregimiento de San Matías, municipio de Gómez Plata, Antioquia, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La leishmaniaisis es una enfermedad encontrada en focos naturales de infección donde están presentes insectos vectores y mamíferos reservorios deLeishmania. Objetivo.
Diana Sierra, Marcela Ochoa, José Ignacio Calle, Gisela García, Diana Colorado, Iván Darío Vélez   +5 more
doaj   +1 more source

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

Nature Communications, 2021
Protein kinases are fundamental in cellular signalling required for Leishmania survival throughout the life cycle. Here, Baker and Catta-Preta et al. report on a kinome-wide functional study in Leishmania mexicana to define protein kinases with roles in ...
N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geoghegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. B. Walrad, L. G. Wilson, J. W. Pitchford, P. Volf, J. C. Mottram   +17 more
doaj   +1 more source

Proteomic analysis of Leishmania mexicana differentiation

Molecular and Biochemical Parasitology, 2004
We have resolved the proteome of axenically differentiated Leishmania mexicana parasites by two-dimensional gel electrophoresis (2DE), employing optimised, robust and reproducible procedures, and visualised (by silver staining) approximately 2000 protein species in each of three developmental stages: procyclic promastigotes, metacyclic promastigotes ...
Nugent, P, Karsani, SA, Wait, R, Tempero, J, Smith, D   +4 more
openaire   +3 more sources

Leishmania (L.) mexicana infected bats in Mexico: novel potential reservoirs.

PLoS Neglected Tropical Diseases, 2015
Leishmania (Leishmania) mexicana causes cutaneous leishmaniasis, an endemic zoonosis affecting a growing number of patients in the southeastern states of Mexico.
Miriam Berzunza-Cruz, Ángel Rodríguez-Moreno, Gabriel Gutiérrez-Granados, Constantino González-Salazar, Christopher R Stephens, Mircea Hidalgo-Mihart, Carlos F Marina, Eduardo A Rebollar-Téllez, Dulce Bailón-Martínez, Cristina Domingo Balcells, Carlos N Ibarra-Cerdeña, Víctor Sánchez-Cordero, Ingeborg Becker   +12 more
doaj   +1 more source

Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico

Journal of Tropical Medicine, 2022
In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to
Erika I. Sosa-Bibiano, Luis A. Sánchez -Martínez, Karina B. López-Ávila, Juan B. Chablé-Santos, Jimmy R. Torres-Castro, Edith A. Fernández-Figueroa, Claudia Rangel-Escareño, Elsy N. Loría-Cervera   +7 more
doaj   +1 more source

Gene editing and scalable functional genomic screening in Leishmania species using the CRISPR/Cas9 cytosine base editor toolbox LeishBASEedit

eLife, 2023
CRISPR/Cas9 gene editing has revolutionised loss-of-function experiments in Leishmania, the causative agent of leishmaniasis. As Leishmania lack a functional non-homologous DNA end joining pathway however, obtaining null mutants typically requires ...
Markus Engstler, Tom Beneke
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Nitric oxide production by Peromyscus yucatanicus (Rodentia) infected with Leishmania (Leishmania) mexicana

Memorias do Instituto Oswaldo Cruz, 2013
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania.
Elsy Nalleli Loría-Cervera, Erika Ivett Sosa-Bibiano, Liliana Estefanía Villanueva-Lizama, Nicole Raymonde Van Wynsberghe, Silvia Beatriz Canto-Lara, José Luis Batún-Cutz, Fernando José Andrade-Narváez   +6 more
doaj   +1 more source

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source