Results 41 to 50 of about 9,040 (224)

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Tarsis F Gesteira, Gesteira Tarsis F., Sanya J Sanderson, Tersariol, Ivarne L.S., Westrop, Gareth, Sansevero, Thiago M., Shida, Claudio S. [UNIFESP], Manfredi, Marcella A, Tersariol, Ivarne Luis dos Santos [UNIFESP], Gerson P Souza, Ivarne L S Tersariol, Luiz Juliano, Manfredi Marcella A., Gareth D Westrop, Sansevero Thiago M., Almeida Paulo C., Tersariol Ivarne L. S., Souza, Gerson A., Manfredi, Marcella A., Sanderson Sanya J., Thiago M Sansevero, Souza, Gerson P., Juliano, Luiz, Westrop, Gareth D., Almeida, Paulo C. [UNIFESP], Judice, W.A.S., Paulo C Almeida, Judice Wagner A. S., Coombs Graham H., Coombs, Graham H., Shida, Claudio S., Shida Cláudio S., Cláudio S Shida, Souza Gerson P., Almeida, Paulo C, Judice, Wagner A. S., Marcella A Manfredi, Sanderson, Sanya J, Coombs, Graham, Juliano, Luiz [UNIFESP], Wagner A S Judice, Juliano Luiz, Sanderson, Sanya J., Graham H Coombs, Westrop Gareth D.   +45 more
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Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG [PDF]

, 2004
Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection.
Bates, Paul A., Ilg, T., Nikolaev, Andrei V., Ferguson, Michael AJ, Andrei V. Nikolaev, Matthew E. Rogers, Ilg, Thomas, Ferguson, Michael A. J.; id_orcid, Ferguson, M. A. J., Rogers, Matthew E., Ferguson, Michael A J, Paul A. Bates, Michael A. J. Ferguson, Rogers, Matthew E, Thomas Ilg, Bates, Paul, Nikolaev, Andrei V, Bates, Paul A, Nikolaev, A. V.   +18 more
core   +1 more source

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms [PDF]

, 1992
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigote-like forms in Schneider's Drosophila medium supplemented with 20% (v/v) foetal calf serum.
Coombs, G H, Robertson, C D, Tetley, L, Bates, P A   +3 more
core  

The role of leishmania proteophosphoglycans in sand fly transmission and infection of the Mammalian host. [PDF]

, 2012
Leishmania are transmitted by the bite of their sand fly vector and this has a significant influence on the virulence of the resulting infection. From our studies into the interaction between parasite, vector, and host we have uncovered an important ...
Rogers, Matthew E, Matthew Edward Rogers, Matthew E. Rogers   +2 more
core   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Leishmania mexicana mexicana: quantitative analysis of the intracellular cycle

Parasitology, 1989
SummaryThe complete intracellular cycle of theLeishmania mexicana mexicanaG. S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line utilizing a culture system that allows the direct observation of individual intracellular parasites.
P S, Doyle, J C, Engel, A A, Gam, J A, Dvorak   +3 more
openaire   +2 more sources

Complete developmental cycle of Leishmania mexicana in axenic culture [PDF]

, 1994
A complete developmental sequence of Leishmania mexicana has been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days.
Bates, P A
core  

Synthetic glycovaccine protects against the bite of leishmania-infected sand flies

, 2006
Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic ...
Bates, Paul A., Nikolaev, Andrei V., Ferguson, Michael AJ, Ferguson, Michael A. J.; id_orcid, Sizova, O. V., Ferguson, M. A. J., Rogers, Matthew E., Ferguson, Michael A J, Rogers, Matthew E, Bates, Paul, Sizova, Olga V, Nikolaev, Andrei V, Bates, Paul A, Sizova, Olga V., Nikolaev, A. V.   +14 more
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source