Results 41 to 50 of about 7,407 (178)

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection

Parasites & Vectors, 2014
Background Phlebotomine sand flies transmit the haemoflagellate Leishmania, the causative agent of human leishmaniasis. The Leishmania promastigotes are confined to the gut lumen and are exposed to the gut microbiota within female sand flies.
Mauricio RV Sant’Anna, Hector Diaz-Albiter, Kelsilândia Aguiar-Martins, Waleed S Al Salem, Reginaldo R Cavalcante, Viv M Dillon, Paul A Bates, Fernando A Genta, Rod J Dillon   +8 more
doaj   +1 more source

IgG1 Is Pathogenic in Leishmania mexicana Infection [PDF]

The Journal of Immunology, 2010
Abstract There are >2 million new cases of leishmaniasis annually, and no effective vaccine has been developed to prevent infection. In murine infection, Leishmania mexicana, which lives intracellularly in host macrophages, has developed pathways to hijack host IgG to induce a suppressive IL-10 response through FcγRs, the cell ...
Niansheng, Chu, Bolaji N, Thomas, Supriya R, Patel, Laurence U, Buxbaum   +3 more
openaire   +2 more sources

Green Synthesis of Metal Oxide Nanoparticles Using Plant Extracts: Applications in Catalysis and Biomedicine

Nano Select, Volume 7, Issue 3, March 2026.
ABSTRACT The green synthesis of metal oxide nanoparticles (MONPs) using plant‐based resources has gained significant traction as an environmentally benign, cost‐effective, and scalable alternative to traditional chemical and physical methods. This review comprehensively explores the plant‐mediated synthesis routes for a variety of MONPs, including CuO,
Faith Mwangi, Jannatun Zia, Ufana Riaz
wiley   +1 more source

Structure of Leishmania mexicana lipophosphoglycan.

Journal of Biological Chemistry, 1992
Lipophosphoglycan (LPG) was isolated from the culture supernatant of Leishmania mexicana promastigotes and its structure elucidated by a combination of 1H NMR, fast atom bombardment mass spectrometry, methylation analysis, and chemical and enzymatic modifications. It consists of the repeating phosphorylated oligosaccharides PO4-6Gal beta 1-4Man alpha 1-
Ilg, Thomas, Etges, Robert, Overath, Peter, McConville, Malcolm J., Thomas-Oates, Jane, Thomas, Jerry, Homans, Steven W., Ferguson, Michael A.   +7 more
openaire   +2 more sources

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Visceral Leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection

Memorias do Instituto Oswaldo Cruz, 2000
A 36 year old male was admitted in December 1997 to hospital with afternoon fever, malaise and hepatosplenomegaly. He also had a dry cough, dyspnoea and anaemia.
Carmen Ramos-Santos, Omar Hernandez-Montes, Gustavo Sanchez-Tejeda, Amalia Monroy-Ostria   +3 more
doaj   +1 more source

Sex‐Specific Factors Influencing HIV Infection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley   +1 more source

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source