Results 221 to 230 of about 13,441 (240)
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Heme binding to Leishmania mexicana amazonensis
Molecular and Biochemical Parasitology, 1988Leishmania mexicana amazonensis is a pathogenic parasite whose growth, due to a biosynthetic deficiency, is dependent on a supply of exogenous heme. Utilizing [55Fe]hemin, we have demonstrated that heme binding to non-dividing cultured promastigotes of L. m.
Galbraith Ra, McElrath Mj
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Leishmania mexicana mexicana gp63 is a site-specific neutral endopeptidase
Molecular and Biochemical Parasitology, 1990Leishmania mexicana, like other species of the genus, has a major 63-kDa surface glycoprotein (gp63) that is an active protease. Reports differ as to whether gp63 is a neutral or an acidic protease. Using three radiolabeled synthetic peptide substrates, gp63 purified from L. m.
Anders Örn +3 more
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Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1985Amastigotes and cultured promastigotes of Leishmania mexicana mexicana and L. m. amazonensis, cultured promastigotes of L. donovani and L. tarentolae, and the culture forms of Crithidia fasciculata, Herpetomonas muscarum muscarum and H. m. ingenoplastis all possessed four phosphoribosyltransferase (PRTase) activities: adenine PRTase, hypoxanthine ...
Husain F. Hassan, Graham H. Coombs
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Molecular and Biochemical Parasitology, 1994
The glycolytic enzyme glucosephosphate isomerase (PGI) is present in two different cell compartments of Leishmania mexicana promastigotes; more than 90% of the activity was detected in the cytosol, the remainder in glycosomes. This subcellular distribution contrasts with that in Trypanosoma brucei, in which the enzyme activity has been mainly located ...
Fred R. Opperdoes +3 more
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The glycolytic enzyme glucosephosphate isomerase (PGI) is present in two different cell compartments of Leishmania mexicana promastigotes; more than 90% of the activity was detected in the cytosol, the remainder in glycosomes. This subcellular distribution contrasts with that in Trypanosoma brucei, in which the enzyme activity has been mainly located ...
Fred R. Opperdoes +3 more
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ANTIPROLIFERATIVE EFFECT OF ILLIMAQUINONE ON LEISHMANIA MEXICANA
Cell Biology International, 1997Illimaquinone, a sponge metabolite that disrupts the Golgi complex in mammalian cells, stopped proliferation and induced morphological and ultrastructural changes in promastigotes of L. mexicana Radioactive labeling of proteins demonstrates an increased excretion function and diminution of membrane acid phosphatase activity, due probably to the ...
F. Dagger +2 more
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Interaction of different Leishmania mexicana morphotypes with plasminogen
Parasitology Research, 2002The interaction of plasminogen with Leishmania mexicana promastigotes was found, using immunoperoxidase assays, to occur with a specific morphotype. In in vitro cultured promastigotes, the morphotype that possessed the plasminogen binding capacity had round to ovoid cell bodies.
Marina Calcagno +4 more
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Inducible protein stabilization system in Leishmania mexicana
Molecular and Biochemical Parasitology, 2017Targeted regulation of protein levels is an important tool to investigate the role of proteins essential for cell function and development. In recent years, methods based on the Escherichia coli dihydrofolate reductase destabilization domain (ecDHFR DD) have been established and used in various cell types.
Huan Huang +2 more
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Molecular and Biochemical Parasitology, 1990
The multiple cysteine proteinases characteristic of the amastigote forms of Leishmania mexicana mexicana have been shown to be of three types. The groups of enzymes are distinguished by their substrate specificities and physical properties and have been purified free from other proteinases and most other proteins.
Colin D. Robertson, Graham H. Coombs
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The multiple cysteine proteinases characteristic of the amastigote forms of Leishmania mexicana mexicana have been shown to be of three types. The groups of enzymes are distinguished by their substrate specificities and physical properties and have been purified free from other proteinases and most other proteins.
Colin D. Robertson, Graham H. Coombs
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Evidence for a Membrane Adenosine Receptor in Leishmania Mexicana Mexicana (WR 227)
1986Leishmania spp., a Protozoan Parasite transmitted to the mammalian host by the sand fly (genus Phlebotomus), produces a disease manifested in the cutaneous, mucocutaneous or visceral form. The choice of drugs has been limited primarily to the pentavalent antimonial compounds.
Jose Perez-Arbelo +2 more
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Leishmania mexicana: Energy metabolism of amastigotes and promastigotes
Experimental Parasitology, 1982Abstract The utilisation of substrates by Leishmania mexicana amastigotes and promastigotes differed significantly. The rates of uptake and catabolism of nonesterified fatty acids were up to 10-fold higher with amastigotes. Almost all the available exogenous fatty acids were consumed during amastigote transformation and by stationary phase of ...
Graham H. Coombs, D.T. Hart
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