Results 31 to 40 of about 5,427 (197)

Mucocutaneous Leishmania tropica infection in a dog from a human cutaneous leishmaniasis focus

Parasites & Vectors, 2014
Background Leishmania tropica is a causative agent of cutaneous leishmanaisis in the Middle East, North Africa and parts of southeastern Europe. Although transmission of L.
Gad Baneth, Doni Zivotofsky, Yaarit Nachum-Biala, Daniel Yasur-Landau, Ana-Maria Botero   +4 more
doaj   +1 more source

Moroccan strains of Leishmania major and Leishmania tropica differentially impact on nitric oxide production by macrophages

Parasites & Vectors, 2017
Background Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by protozoa of the genus Leishmania. In Morocco, CL is a public health problem mainly caused by Leishmania major and Leishmania tropica, which are responsible for zoonotic
Hasnaa Maksouri, Pham My-Chan Dang, Vasco Rodrigues, Jérôme Estaquier, Myriam Riyad, Khadija Akarid   +5 more
doaj   +1 more source

Leishmania cytochrome b gene sequence polymorphisms in southern Iran: relationships with different cutaneous clinical manifestations

BMC Infectious Diseases, 2019
Background Cutaneous leishmaniasis (CL) caused by Leishmania species, is a geographically extensive disease that infects humans and animals. CL is endemic in half of the 31 provinces of Iran, with 29,201 incidence cases reported in Fars province from ...
Iraj Mohammadpour, Gholam Reza Hatam, Farhad Handjani, Farzaneh Bozorg-Ghalati, Daniel PourKamal, Mohammad Hossein Motazedian   +5 more
doaj   +1 more source

Investigating the Existence of Ribosomal Protein L5 Gene in Syrian Strain of Leishmania tropica Genome: Sequencing It and Evaluating Its Immune Response as DNA Vaccine

Journal of Parasitology Research, 2021
Cutaneous leishmaniasis in Syria is caused mainly by Leishmania tropica. It represents a serious health problem, which has aggravated further after the civil war in the country.
Mohammad Maarouf, Alyaa A. Abdlwahab
doaj   +1 more source

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives

ChemMedChem, EarlyView.
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47^phox Phosphorylation

Microorganisms, 2021
Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by Leishmania. They synthetize superoxide anions (O2−) under the control of the NADPH oxidase complex. In Morocco, Leishmania major and L.
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid   +7 more
doaj   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Leishmaniasis in Patients With Inflammatory Bowel Disease: A National Multicenter Study of GETECCU

United European Gastroenterology Journal, Volume 13, Issue 5, Page 674-684, June 2025.
ABSTRACT Background Leishmaniasis (LI) is a vector‐borne illness caused by a protozoan of the genus Leishmania. Data on the features of LI in patients with inflammatory bowel disease (IBD) are scarce. Aim To describe the characteristics of patients with IBD who present with leishmaniasis, infection outcomes and the risk factors associated with ...
L Madero‐Velázquez, A Mínguez, L Mayorga, JJ Ramírez, N Moreno, C Amorós, MA Nieto, R Mena, JM Benítez, L Gimeno‐Pitarch, N Maroto, C Suria, F Rodríguez‐Moranta, I Ordás, L Ruiz, MA García‐Brenes, A Martín‐Cardona, C Rubín de Célix, K Cárdenas, D Ginard, L Medina, N Pedrero, R Plaza, R Salmoral, TJ Martínez‐Pérez, V Algara, E Merino, Y Zabana, A Gutiérrez, on behalf of Young Group of GETECCU   +29 more
wiley   +1 more source

Mesenchymal Stem Cells: A Double‐Edged Approach for Managing Cutaneous Leishmaniasis Lesions

International Wound Journal, Volume 22, Issue 6, June 2025.
ABSTRACT Leishmania spp. are intracellular protozoan parasites responsible for leishmaniasis, a globally prevalent vector‐borne disease transmitted by phlebotomine sandflies. Within vertebrate hosts, the parasites preferentially infect macrophages and dendritic cells, leading to cell lysis and the formation of disfiguring lesions.
Masoud Foroutan, Hamidreza Majidiani, Hany M. Elsheikha, Ali Saeedi‐Boroujeni, Saeed Bahadory, Reza Saberi, Ana Shirzadshahrivar, Seyed Mahmoud Hashemi, Sara Soudi   +8 more
wiley   +1 more source

Spatial Distribution and Molecular Identification of Leishmania Species from Endemic Foci of South-Eastern Iran [PDF]

Iranian Journal of Parasitology, 2012
Background: Cutaneous leishmaniasis constitutes a major public health problem in many parts of the world including Iran. The primary objective of this study was to identify Leishmania species in endemic districts of Kerman Province, south-eastern Iran ...
M Mashayekhi, R Zahmatkesh, M Fasihi Harandi, MR Aflatoonian, M Hakimi Parizi, M Zarean, I Sharifi, F Sharifi, AR Kermanizadeh   +8 more
doaj   +2 more sources