Results 41 to 50 of about 2,272 (172)

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.

, 2005
In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease ...
Croft, Simon L, Cammerer, Simon, Gilbert, Ian H, Orenes Lorente, Silvia, Ruiz Perez, Luis M, Urbina, Julio, Gonzalez Pacanowska, Dolores, Jiménez, Carmen, Pacanowska, Dolores Gonzalez, de Luca-Fradley, Kate, Gómez, Rosario, Perez, Luis M. Ruiz, Gilbert, Ian H., Lorente, Silvia Orenes, Yardley, Vanessa, Croft, Simon L.   +15 more
core   +1 more source

Effects of silver nanoparticle based on ginger extract on Leishmania infantum and Leishmania tropica parasites : in vitro [PDF]

Archives of Razi Institute
Leishmania is the main cause of a serious public health problem called leishmaniasis in Iran. Pentavalent antimonial chemicals are usually used for leishmaniasis treatment. But this drugs have a number of negative side effects, including drug resistance,
Amir Karimipour-saryazdi, Abolhossein Dalimi, Seyyed Hojjat Sadeghi, Zeinab Moghadamizad, Majid Pirestani   +4 more
doaj   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

A real-time PCR assay to estimate Leishmania chagasi load in its natural sand fly vector Lutzomyia longipalpis [PDF]

, 2008
Leishmania chagasi, transmitted mainly by Lutzomyia longipalpis sand flies, causes visceral leishmaniasis and atypical cutaneous leishmaniasis in Latin America.
Bates, Paul A., Maingon, Rhayza D.C., Ranasinghe, Shalindra, Ranasinghe, S., Rogers, Matthew E., Hamilton, J. G. C., Maingon, Rhayza DC, Rogers, Matthew E, Bates, Paul, Hamilton, James G C, Maingon, Rhayza D C, Hamilton, James GC, Maingon, R. D. C., Hamilton, James G.C., Bates, Paul A   +14 more
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Prevalence of Leishmania spp. infection in domestic dogs in Chapare, Bolivia.

, 2011
Data on Leishmania spp. infection in dogs in Bolivia is scarce. Dogs from an area where 90% of human cutaneous leishmaniasis (CL) cases are due to Leishmania (Viannia) braziliensis were screened for Leishmania infection using established enzyme-linked ...
Reithinger, Richard, Mary Cruz Torrico, Parrado, Rudy, Garcia, Ana Lineth, Delgado, Raúl, Richard Reithinger, Torrico, Mary Cruz, Ana Lineth Garcia, Rojas, Ernesto, Rudy Parrado, Ernesto Rojas, Raúl Delgado   +11 more
core   +1 more source

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47^phox Phosphorylation

Microorganisms, 2021
Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by Leishmania. They synthetize superoxide anions (O2−) under the control of the NADPH oxidase complex. In Morocco, Leishmania major and L.
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid   +7 more
doaj   +1 more source