Results 51 to 60 of about 65,392 (160)

Phytotherapy in Leishmania infantum and Leishmania tropica [PDF]

, 2017
Leishmaniasis is a tropical zoonotic disease, transferred from conveyer sandflies. Cutaneous Leishmaniasis is the second common disease after malaria, prevalent in many tropical countries of the world.
Rafieian-Kopaei, M., Abdi, J., Naserifar, R., Bahmani, M., Abbaszadeh, S., Adineh, S. H.   +5 more
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.

, 2005
In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease ...
Croft, Simon L, Cammerer, Simon, Gilbert, Ian H, Orenes Lorente, Silvia, Ruiz Perez, Luis M, Urbina, Julio, Gonzalez Pacanowska, Dolores, Jiménez, Carmen, Pacanowska, Dolores Gonzalez, de Luca-Fradley, Kate, Gómez, Rosario, Perez, Luis M. Ruiz, Gilbert, Ian H., Lorente, Silvia Orenes, Yardley, Vanessa, Croft, Simon L.   +15 more
core   +1 more source

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47^phox Phosphorylation

Microorganisms, 2021
Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by Leishmania. They synthetize superoxide anions (O2−) under the control of the NADPH oxidase complex. In Morocco, Leishmania major and L.
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid   +7 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Spatial Distribution and Molecular Identification of Leishmania Species from Endemic Foci of South-Eastern Iran [PDF]

Iranian Journal of Parasitology, 2012
Background: Cutaneous leishmaniasis constitutes a major public health problem in many parts of the world including Iran. The primary objective of this study was to identify Leishmania spe­cies in endemic districts of Kerman Province, south-eastern Iran.
F Sharifi, I Sharifi, M Zarean, M Hakimi Parizi, MR Aflatoonian, M Fasihi Harandi, R Zahmatkesh, M Mashayekhi, AR Kermanizadeh   +8 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Prevalence of Leishmania spp. infection in domestic dogs in Chapare, Bolivia.

, 2011
Data on Leishmania spp. infection in dogs in Bolivia is scarce. Dogs from an area where 90% of human cutaneous leishmaniasis (CL) cases are due to Leishmania (Viannia) braziliensis were screened for Leishmania infection using established enzyme-linked ...
Reithinger, Richard, Mary Cruz Torrico, Parrado, Rudy, Garcia, Ana Lineth, Delgado, Raúl, Richard Reithinger, Torrico, Mary Cruz, Ana Lineth Garcia, Rojas, Ernesto, Rudy Parrado, Ernesto Rojas, Raúl Delgado   +11 more
core   +1 more source

Lupoid leishmaniasis among the known cases of cutaneous leishmaniasis in Herat Province, western Afghanistan

Journal of Infection and Public Health, 2016
Summary: Lupoid cutaneous leishmaniasis (LCL) is an uncommon form of chronic cutaneous leishmaniasis, which is mostly caused by Leishmania tropica in the Old World and has a high incidence throughout early life.
Hossein Pazoki, Mahdi Fakhar, Abobakar Rasooli, Mehdi Karamian, Eisa Nazar   +4 more
doaj   +1 more source

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites. [PDF]

PLoS Neglected Tropical Diseases, 2017
Proliferation of Leishmania (L.) parasites depends on polyamine availability, which can be generated by the L-arginine catabolism and the enzymatic activity of arginase (ARG) of the parasites and of the mammalian hosts.
Alireza Badirzadeh, Tahereh Taheri, Yasaman Taslimi, Zahra Abdossamadi, Maryam Heidari-Kharaji, Elham Gholami, Baharehsadat Sedaghat, Maryam Niyyati, Sima Rafati   +8 more
doaj   +1 more source