Results 61 to 70 of about 17,699 (240)

The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47^phox Phosphorylation

Microorganisms, 2021
Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by Leishmania. They synthetize superoxide anions (O2−) under the control of the NADPH oxidase complex. In Morocco, Leishmania major and L.
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid   +7 more
doaj   +1 more source

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Barberry (Berberis vulgaris) root extract shows potential in treating cutaneous leishmaniasis caused by Leishmania major. In a BALB/c mouse model, treatment significantly reduced wound size and parasite load while enhancing inflammatory markers IL‐1 and IL‐6. These results highlight barberry's therapeutic promise against leishmaniasis.
Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam   +3 more
wiley   +1 more source

Spatial Distribution and Molecular Identification of Leishmania Species from Endemic Foci of South-Eastern Iran [PDF]

Iranian Journal of Parasitology, 2012
Background: Cutaneous leishmaniasis constitutes a major public health problem in many parts of the world including Iran. The primary objective of this study was to identify Leishmania species in endemic districts of Kerman Province, south-eastern Iran ...
M Mashayekhi, R Zahmatkesh, M Fasihi Harandi, MR Aflatoonian, M Hakimi Parizi, M Zarean, I Sharifi, F Sharifi, AR Kermanizadeh   +8 more
doaj   +2 more sources

Development of a rapid loop-mediated isothermal amplification assay for diagnosis and assessment of cure of Leishmania infection [PDF]

, 2017
BACKGROUND: Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel.
Narendra Singh Negi, Poonam Salotra, Ram Avtar Bumb, Ruchi Singh, Sandeep Verma, V Ramesh, Vanila Sharma   +6 more
core   +1 more source

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

Detection, molecular typing and phylogenetic analysis of Leishmania isolated from cases of leishmaniasis among Syrian refugees in Lebanon

Parasite Epidemiology and Control, 2016
Leishmania is a parasitic protozoan with more than two-dozen species causing the disease leishmaniasis. It is transmitted to humans through the bite of an infected female phlebotomine sand-fly vector.
Tamara Salloum, Ibrahim Khalifeh, Sima Tokajian   +2 more
doaj   +1 more source

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites. [PDF]

PLoS Neglected Tropical Diseases, 2017
Proliferation of Leishmania (L.) parasites depends on polyamine availability, which can be generated by the L-arginine catabolism and the enzymatic activity of arginase (ARG) of the parasites and of the mammalian hosts.
Alireza Badirzadeh, Tahereh Taheri, Yasaman Taslimi, Zahra Abdossamadi, Maryam Heidari-Kharaji, Elham Gholami, Baharehsadat Sedaghat, Maryam Niyyati, Sima Rafati   +8 more
doaj   +1 more source

Sequence analysis of the 3-untranslated region of HSP70 (type I) genes in the genus Leishmania: Its usefulness as a molecular marker for species identification [PDF]

, 2015
Background: The Leishmaniases are a group of clinically diverse diseases caused by parasites of the genus Leishmania. To distinguish between species is crucial for correct diagnosis and prognosis as well as for treatment decisions.
Cañavate, Carmen, Chicharro, Carmen, García, Lineth, Parrado, Rudy, Puerta, Concepción J., Requena, José María   +5 more
core   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Molecular detection of Leishmania species in human and animals from cutaneous leishmaniasis endemic areas of Waziristan, Khyber Pakhtunkhwa, Pakistan

Asian Pacific Journal of Tropical Medicine, 2018
Objectives: To detect Leishmania species in human patients, animal reservoirs and Phlebotomus sandflies in Waziristan, Pakistan. Methods: Tissue smears and aspirates from 448 cutaneous leishmaniasis (CL) suspected patients were analyzed. To sort out role
Mubashir Hussain, Shahzad Munir, Abdullah Jalal, Taj Ali Khan, Niaz Muhammad, Bahar Ullah Khattak, Abdullah Khan, Irfan Ahmed, Zulqarnain Baloch, Nawaz Haider Bashir, Muhammad Ameen Jamal, Kashif Rahim, Humaira Mazhar, Maira Riaz, Noha Watany   +14 more
doaj   +1 more source