Results 1 to 10 of about 11,204 (214)

Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Until 2015, loss-of-function studies to elucidate protein function in Leishmania relied on gene disruption through homologous recombination. Then, the CRISPR/Cas9 revolution reached these protozoan parasites allowing efficient genome editing with one ...
Caroline R. Espada, Caroline R. Espada, José Carlos Quilles, Andreia Albuquerque-Wendt, Andreia Albuquerque-Wendt, Andreia Albuquerque-Wendt, Mario C. Cruz, Tom Beneke, Lucas B. Lorenzon, Eva Gluenz, Eva Gluenz, Angela K. Cruz, Silvia R. B. Uliana   +12 more
doaj   +3 more sources

Assessing reservoir host status in leishmaniasis with special reference to the infectiousness of Leishmania (Viannia) braziliensis infections in wild rodents. [PDF]

Rev Soc Bras Med Trop, 2023
Molecular methods have been responsible for a notable increase in the detection of Leishmaniinae infections in wild animals. Determining their infectiousness is of paramount importance in evaluating their epidemiological significance.
Shaw JJ, Marinho-Júnior JF, Courtenay O, Brandão-Filho SP.   +3 more
europepmc   +2 more sources

Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis. [PDF]

Front Cell Infect Microbiol, 2022
Leishmaniasis is a parasitic disease caused by several species of intracellular protozoa of the genus Leishmania that present manifestations ranging from cutaneous ulcers to the fatal visceral form. Leishmania Viannia braziliensis is an important species
Dos Santos RF, Da Silva T, Brito ACS, Inácio JD, Ventura BD, Mendes MAP, Azevedo BF, Siqueira LM, Almeida-Amaral EE, Dutra PML, Da-Silva SAG.   +10 more
europepmc   +2 more sources

Evidence of Guanidines Potential against Leishmania (Viannia) braziliensis: Exploring In Vitro Effectiveness, Toxicities and of Innate Immunity Response Effects. [PDF]

Biomolecules, 2023
Leishmaniasis is a complex group of infectious and parasitic diseases that afflict many thousands of individuals across five continents. Leishmaniasis treatment remains a challenge because it relies on drugsknown for their high toxicity and limited ...
Dos Anjos LR, de Souza VMR, Machado YAA, Partite VM, Aufy M, Dias Lopes G, Studenik C, Alves CR, Lubec G, Gonzalez ERP, Rodrigues KADF.   +10 more
europepmc   +2 more sources

High levels of infectiousness of asymptomatic Leishmania (Viannia) braziliensis infections in wild rodents highlights their importance in the epidemiology of American Tegumentary Leishmaniasis in Brazil. [PDF]

PLoS Negl Trop Dis, 2023
Background The epidemiological significance of wildlife infections with aetiological agents causing human infectious diseases is largely determined by their infection status, contact potential with humans (via vectors for vector-borne diseases), and ...
Marinho-Júnior JF, Monteiro JFCLS, Sales de Carvalho AW, de Carvalho FG, de Paiva Cavalcanti M, Shaw J, Courtenay O, Brandão-Filho SP.   +7 more
europepmc   +2 more sources

Clinical Presentation of American Tegumentary Leishmaniasis in a Leishmania (Viannia) braziliensis Endemic Hotspot: A 35-Year History. [PDF]

Am J Trop Med Hyg, 2023
American tegumentary leishmaniasis (ATL) is a neglected tropical disease affecting the skin and mucosa. American tegumentary leishmaniasis due to Leishmania (Viannia) braziliensis is endemic in Argentina, where the Department of Oran is a hyperendemic ...
Almazán MC, Cajal SP, Díaz-Fernández M, Juárez M, Quipildor M, Portal G, Tejerina V, Vargas C, Copa GN, Gil JF, Cimino RO, Krolewiecki AJ.   +11 more
europepmc   +2 more sources

Central and Effector Memory Human CD4+ and CD8+ T Cells during Cutaneous Leishmaniasis and after In Vitro Stimulation with Leishmania (Viannia) braziliensis Epitopes [PDF]

Vaccines (Basel), 2023
Cutaneous Leishmaniasis (CL) is a Neglected Tropical Disease characterized by skin ulcers caused by Leishmania spp. protozoans and there is no safe and effective vaccine to reduce its negative consequences.
de Oliveira BC, da Silva AA, de Andrade Cavalcante MK, de Brito MEF, de Castro MCAB, de Medeiros VLS, de Freitas E Silva R, Pereira VRA.   +7 more
europepmc   +2 more sources

Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle. [PDF]

PLoS Negl Trop Dis, 2022
Background Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis is highly prevalent in the Peruvian jungle, where it affects military forces deployed to fight against drug trafficking and civilian people that migrate from the ...
De Los Santos MB, Ramírez IM, Rodríguez JE, Beerli P, Valdivia HO.   +4 more
europepmc   +2 more sources

Incidence of Human and Free-Ranging Wild Rodent Infections with Leishmania (Viannia) braziliensis, Aetiological Agent of Cutaneous Leishmaniasis. [PDF]

Pathogens, 2023
Background. Human and wild rodent infection rates with Leishmania (Viannia) braziliensis are needed to differentiate transmission pathways in anthropogenically altered habitats. Methods.
Courtenay O, Marinho-Júnior JF, Brito MEF, Monteiro JFCLS, Shaw JJ, Brandão-Filho SP.   +5 more
europepmc   +2 more sources

First report of Leishmania RNA virus 1 in Leishmania (Viannia) braziliensis clinical isolates from Rio de Janeiro State - Brazil. [PDF]

Mem Inst Oswaldo Cruz, 2022
BACKGROUND Leishmania parasites carry a double-stranded RNA virus (Leishmania RNA virus - LRV) that has been divided in LRV1 and LRV2. OBJECTIVES Leishmania (Viannia) braziliensis clinical isolates were assessed in order to determine LRV presence ...
Zabala-Peñafiel A, Fantinatti M, Dias-Lopes G, da Silva JL, Miranda LFC, Lyra MR, Pimentel MIF, Conceição-Silva F, Alves CR.   +8 more
europepmc   +2 more sources