Results 101 to 110 of about 180,299 (231)

Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria

Journal of Internal Medicine, Volume 297, Issue 3, Page 312-327, March 2025.
Abstract Background: Five fulfilled hemophagocytic lymphohistiocytosis (HLH)‐2004 criteria, and the HScore are widely used and recommended by international expert consensus to diagnose secondary HLH. Both diagnostic scores have never been validated in heterogeneous patient cohorts of secondary HLH patients.
Gunnar Lachmann, Patrick Heeren, Friederike S. Schuster, Peter Nyvlt, Claudia Spies, Insa Feinkohl, Thomas Schenk, Wafa Ammouri, France Debaugnies, Lionel Galicier, Yuan Jia, Nikhil Meena, Carole Nagant, Olaf Neth, Stefan Nierkens, Juan San Martin, Hao Wei (Linda) Sun, Yini Wang, Zhao Wang, Jae‐Ho Yoon, Frank M. Brunkhorst, Paul La Rosée, Gritta Janka, Cornelia Lachmann   +23 more
wiley   +1 more source

Interventions for visceral leishmaniasis

Cochrane Database of Systematic Reviews, 2010
Reason for withdrawal from publication This protocol is being withdrawn from The Cochrane Library. The authors have made no progress with this protocol in seven years. The protocol is out of date and does not meet the current methodological standards of Cochrane.
Urbà González, Soumik Kalita, Shyam Sundar, Iván D. Vélez, Mariona Pinart, Mercè Herrero, Jorge Alvar   +6 more
openaire   +3 more sources

Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis

PLoS Pathogens, 2017
Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response ...
B. M. Abidin, Akil Hammami, S. Stäger, Krista M. Heinonen   +3 more
semanticscholar   +1 more source

Tame topology over definable uniform structures [PDF]

arXiv, 2015
A visceral structure on M is given by a definable base for a uniform topology on its universe in which all basic open sets are infinite and any infinite definable subset X of M has non-empty interior. This context includes o-minimal ordered groups, p-adic fields, and other examples.
arxiv  

Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis

International Journal of Nanomedicine, 2017
Visceral leishmaniasis (VL) is a fatal, vector-borne disease caused by the intracellular protozoa of the genus Leishmania. Most of the therapeutics for VL are toxic, expensive, or ineffective.
Muzamil Y Want, Mohammad Islammudin, Garima Chouhan, H. Ozbak, H. Hemeg, A. Chattopadhyay, F. Afrin   +6 more
semanticscholar   +1 more source

Zoonotic Host Richness in the Global Wildland–Urban Interface

Global Change Biology, Volume 31, Issue 2, February 2025.
In the wildland–urban interface (WUI), where human settlements abut or intermix with wildlands, people may encounter animals that host zoonotic pathogens, which can spillover to cause human disease. We map the distribution of zoonotic hosts in the global WUI and show that large populations in tropical low–middle‐income countries (LMICs) are potentially
Rohan D. Simkin, Barbara A. Han, Volker C. Radeloff, Shannon LaDeau, Franz Schug, Karen C. Seto   +5 more
wiley   +1 more source

Recent developments and future prospects in the treatment of visceral leishmaniasis

Therapeutic Advances in Infectious Disease, 2016
Limited therapeutic options in visceral leishmaniasis (VL) make the treatment of this neglected disease very challenging. In addition to this, long treatment duration and toxic adverse effects make it even more difficult.
S. Sundar, Anup Singh
semanticscholar   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

An insight into acupoints and meridians in human body based on interstitial fluid circulation [PDF]

arXiv, 2020
The atlas of human acupoints and meridians has been utilized in clinical practice for almost a millennium although the anatomical structures and functions remain to be clarified. It has recently been reported that a long-distance interstitial fluid (ISF) circulatory pathway may originate from the acupoints in the extremities.
arxiv  

Drug Resistance in Visceral Leishmaniasis [PDF]

Journal of Biomedicine and Biotechnology, 2010
Visceral leishmaniasis remains a public health problem worldwide. This illness was included by the World Health Organization in the list of neglected tropical diseases targeted for elimination by 2015. The widespread emergence of resistance to pentavalent antimonials in India where half cases occur globally and the unavailability of a vaccine in ...
openaire   +3 more sources