Results 21 to 30 of about 38,005 (190)

Life Cycle Stage-Specific Accessibility of Leishmania donovani Chromatin at Transcription Start Regions

mSystems, 2021
Leishmaniacistrans
Janne Grünebast, Stephan Lorenzen, Julia Zummack, Joachim Clos   +3 more
doaj   +3 more sources

Evaluation of a new live recombinant vaccine against cutaneous leishmaniasis in BALB/c mice

Parasites & Vectors, 2020
Background Leishmaniasis is a serious health problem in some parts of the world. In spite of the many known leishmaniasis control measures, the disease has continued to increase in endemic areas, and no effective vaccine has been discovered.
Samira Salari, Iraj Sharifi, Ali Reza Keyhani, Pooya Ghasemi Nejad Almani   +3 more
doaj   +1 more source

Post-Kala-Azar Dermal Leishmaniasis: A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIV/AIDS Patients

Journal of Tropical Medicine, 2013
Visceral leishmaniasis (VL) is a parasitic disease characterized by immune suppression. Successful treatment is usually followed by immune reconstitution and a dermatosis called post-Kala-azar dermal leishmaniasis (PKDL).
Eltahir Awad Gasim Khalil, Selma Abdelmoneim Khidir, Ahmed Mudawi Musa, Brema Younis Musa, Mona Elfaki Eltahir Elfaki, Abdelgadir Mohamed Yousif Elkadaru, Edward Zijlstra, Ahmed Mohamed El-Hassan   +7 more
doaj   +1 more source

Leishmaniasis Parasite Segmentation and Classification using Deep Learning [PDF]

Articulated Motion and Deformable Objects, Series volume 10945 , 2018, Springer International Publishing AG, part of Springer Nature, 2018
Leishmaniasis is considered a neglected disease that causes thousands of deaths annually in some tropical and subtropical countries. There are various techniques to diagnose leishmaniasis of which manual microscopy is considered to be the gold standard.
arxiv   +1 more source

Loop-Mediated Isothermal Amplification Allows Rapid, Simple and Accurate Molecular Diagnosis of Human Cutaneous and Visceral Leishmaniasis Caused by Leishmania infantum When Compared to PCR

Microorganisms, 2021
Loop-mediated isothermal amplification allows the rapid, sensitive and specific amplification of DNA without complex and expensive equipment. We compared the diagnostic performance of Loopamp™ Leishmania Detection Kit (Eiken Chemical Co., Ltd., Tokyo ...
Ana Victoria Ibarra-Meneses, Carmen Chicharro, Carmen Sánchez, Emilia García, Sheila Ortega, Joseph Mathu Ndung’u, Javier Moreno, Israel Cruz, Eugenia Carrillo   +8 more
doaj   +1 more source

Treatment-Based Strategy for the Management of Post-Kala-Azar Dermal Leishmaniasis Patients in the Sudan

Journal of Tropical Medicine, 2013
Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis that affects more than 50% of successfully treated visceral leishmaniasis (VL) patients in Sudan.
A. M. Musa, E. A. G. Khalil, B. M. Younis, M. E. E. Elfaki, M. Y. Elamin, A. O. A. Adam, H. A. A. Mohamed, M. M. M. Dafalla, A. A. Abuzaid, A. M. El-Hassan   +9 more
doaj   +1 more source

Visceral leishmaniasis-hepatitis B/C coinfections: a rising necessity to triage patients for treatment

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In Sudan, VL is caused by L donovani. Most drugs used to treat VL, especially pentavalent antimony compounds (sodium stibogluconate, SSG),
Abubakr O. A. Adam, Mohamed M. M. Dafalla, Hatim A. A. Mohammed, Mohamed Y. Elamin, Brima M. Younis, Mona E. E. Elfaki, Ahmed M. Musa, Ahmed M. Elhassan, Eltahir A. G. Khalil   +8 more
doaj   +1 more source

Transient superdiffusion and long-range correlations in the motility patterns of trypanosomatid flagellate protozoa [PDF]

PLoS ONE 11(3): e0152092 (2016), 2016
We report on a diffusive analysis of the motion of flagellate protozoa species. These parasites are the etiological agents of neglected tropical diseases: leishmaniasis caused by Leishmania amazonensis and Leishmania braziliensis, African sleeping sickness caused by Trypanosoma brucei, and Chagas disease caused by Trypanosoma cruzi.
arxiv   +1 more source

Vaccination with Leishmania mexicana LPG induces PD-1 in CD8+ and PD-L2 in macrophages thereby suppressing the immune response: A model to assess vaccine efficacy [PDF]

Vaccine Volume 32, Issue 11, 5 March 2014, Pages 1259-1265, 2019
Leishmania lipophosphoglycan is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+ lymphocytes and it is ligand PD-L2 in macrophages of BALB/c mice immunized with various ...
arxiv   +1 more source

Anti-Leishmanial and Immunomodulatory Effects of Epigallocatechin 3-O-Gallate on Leishmania tropica: Apoptosis and Gene Expression Profiling

Iranian Journal of Parasitology, 2019
Background: Pentavalent antimonials such as meglumine antimoniate (MA, Glucantime), are the first-line treatment against leishmaniasis, but at present, they have basically lost their efficacy. This study was aimed to explore epigallocatechin 3-O-gallate (
Morteza SADUQI, Iraj SHARIFI, Zahra BABAEI, Alireza KEYHANI, Mahshid MOSTAFAVI, Maryam HAKIMI PARIZI, Mahdiyeh GHASEMIAN, Mehdi BAMOROVAT, Fatemeh SHARIFI, Mohammad Reza AFLATOONIAN, Fariba SHARIFIFAR, Pooya GHASEMI NEJAD, Ahmad KHOSRAVI, Ehsan SALARKIA, Rajender S. VARMA   +14 more
doaj   +1 more source