Results 21 to 30 of about 44,297 (184)

Treatment-Based Strategy for the Management of Post-Kala-Azar Dermal Leishmaniasis Patients in the Sudan

Journal of Tropical Medicine, 2013
Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis that affects more than 50% of successfully treated visceral leishmaniasis (VL) patients in Sudan.
A. M. Musa, E. A. G. Khalil, B. M. Younis, M. E. E. Elfaki, M. Y. Elamin, A. O. A. Adam, H. A. A. Mohamed, M. M. M. Dafalla, A. A. Abuzaid, A. M. El-Hassan   +9 more
doaj   +1 more source

Visceral leishmaniasis-hepatitis B/C coinfections: a rising necessity to triage patients for treatment

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In Sudan, VL is caused by L donovani. Most drugs used to treat VL, especially pentavalent antimony compounds (sodium stibogluconate, SSG),
Abubakr O. A. Adam, Mohamed M. M. Dafalla, Hatim A. A. Mohammed, Mohamed Y. Elamin, Brima M. Younis, Mona E. E. Elfaki, Ahmed M. Musa, Ahmed M. Elhassan, Eltahir A. G. Khalil   +8 more
doaj   +1 more source

Life Cycle Stage-Specific Accessibility of Leishmania donovani Chromatin at Transcription Start Regions

mSystems, 2021
Leishmaniacistrans
Janne Grünebast, Stephan Lorenzen, Julia Zummack, Joachim Clos   +3 more
doaj   +3 more sources

Loop-Mediated Isothermal Amplification Allows Rapid, Simple and Accurate Molecular Diagnosis of Human Cutaneous and Visceral Leishmaniasis Caused by Leishmania infantum When Compared to PCR

Microorganisms, 2021
Loop-mediated isothermal amplification allows the rapid, sensitive and specific amplification of DNA without complex and expensive equipment. We compared the diagnostic performance of Loopamp™ Leishmania Detection Kit (Eiken Chemical Co., Ltd., Tokyo ...
Ana Victoria Ibarra-Meneses, Carmen Chicharro, Carmen Sánchez, Emilia García, Sheila Ortega, Joseph Mathu Ndung’u, Javier Moreno, Israel Cruz, Eugenia Carrillo   +8 more
doaj   +1 more source

Anti-Leishmanial and Immunomodulatory Effects of Epigallocatechin 3-O-Gallate on Leishmania tropica: Apoptosis and Gene Expression Profiling

Iranian Journal of Parasitology, 2019
Background: Pentavalent antimonials such as meglumine antimoniate (MA, Glucantime), are the first-line treatment against leishmaniasis, but at present, they have basically lost their efficacy. This study was aimed to explore epigallocatechin 3-O-gallate (
Morteza SADUQI, Iraj SHARIFI, Zahra BABAEI, Alireza KEYHANI, Mahshid MOSTAFAVI, Maryam HAKIMI PARIZI, Mahdiyeh GHASEMIAN, Mehdi BAMOROVAT, Fatemeh SHARIFI, Mohammad Reza AFLATOONIAN, Fariba SHARIFIFAR, Pooya GHASEMI NEJAD, Ahmad KHOSRAVI, Ehsan SALARKIA, Rajender S. VARMA   +14 more
doaj   +1 more source

The potential role and apoptotic profile of three medicinal plant extracts on Leishmania tropica by MTT assay, macrophage model and flow cytometry analysis

Parasite Epidemiology and Control, 2021
Introduction: Treatment of leishmaniasis with conventional synthetic drugs is a major global challenge. This study was designed to explore the leishmanicidal activity and apoptotic profile of three leaf extracts on Leishmania tropica stages. Methods: The
Mozhde Ilaghi, Iraj Sharifi, Fariba Sharififar, Fatemeh Sharifi, Razieh Tavakoli Oliaee, Zahra Babaei, Manzume Shamsi Meimamandi, Alireza Keyhani, Mehdi Bamorovat   +8 more
doaj   +1 more source

Leishmania: Responding to environmental signals and challenges without regulated transcription

Computational and Structural Biotechnology Journal, 2020
Here we describe the non-canonical control of gene expression in Leishmania, a single-cell parasite that is responsible for one of the major neglected tropical diseases.
Janne Grünebast, Joachim Clos
doaj   +1 more source

Health System Resilience and Afghan Refugee Health in Pakistan: An Exploratory Study of Challenges and Pathways to Inclusion

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Pakistan has hosted Afghan refugees for more than four decades, in one of the world's most protracted displacements of people. Afghan refugees receive health services through United Nations High Commissioner for Refugees (UNHCR) and non‐governmental organisation (NGO) supported programmes alongside public sector facilities at every tier.
Zahid Ali Memon, Asma Ummad, Amina Olabi, Natasha Palmer, Sophie Witter   +4 more
wiley   +1 more source

Leishmania RNA Virus and Its Impact on Drug Response and Clinical Outcomes in Leishmaniasis: A Comprehensive Review

Journal of Parasitology Research
Leishmania RNA viruses (LRVs) have emerged as significant modulators of disease severity, therapeutic response, and clinical outcomes in various forms of leishmaniasis.
Azadeh Zolfaghari, Sarah Seyedyousefi, Zabihollah Shahmoradi, Erfan Zaker, Bahman Rahimi Esboei   +4 more
doaj   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source