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Drug resistance and treatment failure in leishmaniasis: A 21st century challenge
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem.
A. Ponte-Sucre+8 more
semanticscholar +1 more source
Visceral leishmaniasis: a global overview
The leishmaniases are protozoan infections that are among the neglected tropical diseases (NTDs). Over one billion people are at risk of these diseases in virtually all continents. These diseases debilitate large numbers of people, keeping them from full,
R. Wamai, J. Kahn, J. McGloin, G. Ziaggi
semanticscholar +1 more source
Leishmaniasis in Germany [PDF]
In 2000, a reference center was created to systematically record leishmaniases in Germany. We analyzed 58 cases of leishmaniases imported during a 2-year period. These findings will serve as a baseline for the sandfly vector's anticipated northward move because of global warming and as an advisory for immunocompromised persons traveling to ...
Gundel Harms+2 more
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As one of the neglected tropical diseases, leishmaniasis is defined as a parasitic communicable disease that is most prevalent in tropical and subtropical regions, affecting especially populations living in poverty. It has a profound negative impact on developing economies.
Alvaro Sosa-Liprandi+11 more
openaire +4 more sources
Transient superdiffusion and long-range correlations in the motility patterns of trypanosomatid flagellate protozoa [PDF]
We report on a diffusive analysis of the motion of flagellate protozoa species. These parasites are the etiological agents of neglected tropical diseases: leishmaniasis caused by Leishmania amazonensis and Leishmania braziliensis, African sleeping sickness caused by Trypanosoma brucei, and Chagas disease caused by Trypanosoma cruzi.
arxiv +1 more source
A Case Report of a Successful Allergen Immunotherapy with Candida Albicans in Patient with Sever Atopic Dermatitis Sensitive to Candida Albicans [PDF]
Introduction: Atopic dermatitis (AD) is an inflammatory, chronic, relapsing, itchy skin disease with an immunologic basis. This disease is associated with itchy skin lesions (pruritus), dry skin (xerosis) and plaques of eczema. The role of aeroallergens,
Farahzad Jabbari Azad+3 more
doaj +1 more source
Vaccination with Leishmania mexicana LPG induces PD-1 in CD8+ and PD-L2 in macrophages thereby suppressing the immune response: A model to assess vaccine efficacy [PDF]
Leishmania lipophosphoglycan is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+ lymphocytes and it is ligand PD-L2 in macrophages of BALB/c mice immunized with various ...
arxiv +1 more source
Grenander--Stone estimator: stacked constrained estimation of a discrete distribution over a general directed acyclic graph [PDF]
In this paper we integrate isotonic regression with Stone's cross-validation-based method to estimate a distribution with a general countable support with a partial order relation defined on it. We prove that the estimator is strongly consistent for any underlying distribution, derive its rate of convergence, and in the case of one-dimensional support ...
arxiv
Background: Pentavalent antimonials such as meglumine antimoniate (MA, Glucantime), are the first-line treatment against leishmaniasis, but at present, they have basically lost their efficacy. This study was aimed to explore epigallocatechin 3-O-gallate (
Morteza SADUQI+14 more
doaj +1 more source
SummaryLeishmaniasis is a clinically heterogeneous group of diseases, caused by infection with protozoa of the genus Leishmania. The aggressiveness of the individual species, their organ preference and the host immune status determine disease course.
openaire +2 more sources