Results 71 to 80 of about 8,590,312 (311)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The relationship of protein conservation and sequence length

BMC Evolutionary Biology, 2002
Background In general, the length of a protein sequence is determined by its function and the wide variance in the lengths of an organism's proteins reflects the diversity of specific functional roles for these proteins.
Panchenko Anna R, Koonin Eugene V, Souvorov Alexander, Lipman David J, Tatusova Tatiana A   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Relationship between interpersonal sensitivity and leukocyte telomere length

BMC Medical Genetics, 2017
Background Telomeres are repetitive DNA sequences located at the ends of chromosomes, and telomere length represents a biological marker for cellular aging.
Akihito Suzuki, Yoshihiko Matsumoto, Masanori Enokido, Toshinori Shirata, Kaoru Goto, Koichi Otani   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Telomere Length and Distribution in Three Developmental Stages [PDF]

, 2014
Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core  

Length-weight relationship of the seven most numerous octopod species. Scale of axes differs between species due to size differences.

, 2019
Length-weight relationship of the seven most numerous octopod species. Scale of axes differs between species due to size differences.
Henk-Jan Hoving (6945260), Uwe Piatkowski (459725), Richard Schwarz (6945257), Christoph Noever (4225327)   +3 more
core   +1 more source

Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats

Skeletal Muscle
Background Older adults exhibit a slower recovery of muscle mass following disuse atrophy than young adults. At a smaller scale, muscle fibre cross-sectional area (i.e., sarcomeres in parallel) exhibits this same pattern.
Avery Hinks, Geoffrey A. Power
doaj   +1 more source

Relationship Between Retinal Vein Occlusion and Axial Length

Kaohsiung Journal of Medical Sciences, 2003
This study examined whether axial length is a local risk factor for central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). The study group consisted of 40 patients with unilateral CRVO and 77 patients with unilateral BRVO.
San-Chang Tsai, Hsin-Yi Chen
doaj   +1 more source

Relationship Between Foot Length and Gestational Age in Pakistan

Global Pediatric Health, 2020
Preterm births have a high risk of mortality. Therefore, knowledge of the gestational age (GA) at birth is crucial to guide the appropriate management of a newborn.
Shiyam Sunder Tikmani MSc, Sana Roujani MSc, Syed Iqbal Azam MSc, Haleema Yasmin FCPS, Khadija Bano FCPS, Saleem Jessani MSc, Sayyeda Reza MSc, Elizabeth M. McClure PhD, Robert L. Goldenberg MD, Sarah Saleem FCPS   +9 more
doaj   +1 more source