Results 61 to 70 of about 6,804,949 (307)

Telomeres and Telomere Length: A General Overview

Cancers, 2020
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity.
Nalini Srinivas, S. Rachakonda, Rajiv Kumar   +2 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

The relationship between the PICC tip position and weight gain, length growth of premature infants under ultrasonography: a correlation analysis study

Frontiers in Medicine, 2023
ObjectiveThis study aimed to analyze the correlation between PICC tip position and weight/length changes in preterm infants in different positions using ultrasonography.MethodsThe study is a prospective before and after self-control clinical trial.
Xiaojun Tao, Xianhong Zhang, Jianhui Wang, Yanhan Chen, Xuexiu Liu   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Reduction of oxygen content in laser powder bed fusion process atmosphere – Effects on stochastic defect formation and mechanical properties

Journal of Materials Research and Technology
Stochastic defects in materials manufactured via laser powder bed fusion (LPBF) can severely compromise mechanical performance and are challenging to predict and detect, thus motivating the development of defect mitigation strategies.
Claudia Schwerz, Johan Moverare, Alain Kung, Benjamin A. Bircher, Dmitri Riabov, Lars Nyborg   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Mechanical properties of Hastelloy X produced by laser powder bed fusion and affected by spatter redeposition

Journal of Materials Research and Technology
Defects in materials manufactured via laser powder bed fusion challenge this manufacturing process' dependability and may prevent it from being comprehensively used for structural components, particularly those intended to operate under dynamic loading ...
Claudia Schwerz, Johan Moverare, Vishal Sundar, Benjamin A. Bircher, Alain Küng, Dmitri Riabov, Lars Nyborg   +6 more
doaj   +1 more source