Results 91 to 100 of about 611,994 (356)

Factors associated with prolonged length of stay in older patients.

Singapore medical journal, 2017
INTRODUCTION Prolonged stay in acute hospitals increases the risk of hospital-acquired infections in older patients, and disrupts patient flow and access to care due to bed shortages.
H. J. Toh, Z. Y. Lim, P. Yap, Terence Tang   +3 more
semanticscholar   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Rapid decrease in length of stay in institutional care for older people in Sweden between 2006 and 2012: results from a population-based study.

Health and Social Care in the community, 2016
There is limited knowledge about older people's length of stay (time until death) in institutional care and how it has changed over time. The aim of this study was to analyse changes in the length of stay for older people in institutional care between ...
P. Schön, M. Lagergren, I. Kåreholt
semanticscholar   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Time Series Analysis of Emergency Department Length of Stay per 8-Hour Shift

Western Journal of Emergency Medicine, 2012
Introduction: The mean emergency department (ED) length of stay (LOS) is considered a measure ofcrowding. This paper measures the association between LOS and factors that potentially contribute toLOS measured over consecutive shifts in the ED: shift 1 (7:
Niels K. Rathlev, MD, Dan Obendorfer, MBA, Laura F. White, PhD, Casey Rebholz, MPH, Brendan Magauran, MD, MBA, Willie Baker, MD, Andrew Ulrich, MD, Linda Fisher, RN, Jonathan Olshaker, MD   +8 more
doaj  

Volume de fluído intravenoso e alta hospitalar precoce em colecistectomia aberta

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Investigar se a adoção de um protocolo de restrição hídrica intravenosa em colecistectomia aberta diminui a permanência hospitalar. MÉTODO: Estudo prospectivo envolvendo pacientes submetidas a colecistectomia aberta após a adoção de um ...
José Eduardo de Aguilar-Nascimento, Alberto Bicudo-Salomão, Cervantes Caporossi, Raquel de Melo Silva, Eduardo Antonio Cardoso, Tiago Pádua Santos   +5 more
doaj   +1 more source

Hubungan antara Kadar Serum Albumin Awal dengan Lama Rawat Inap dan Status Pulang Pasien Dewasa di Rumah Sakit

Jurnal Gizi Klinik Indonesia, 2004
Background: Several community studies have reported a relationship between a low serum albumin level and increased risk of hospital death, nosocomial infection, and length of stay. But this kind of study is still lacking in Indonesia.
Weni Kurdanti, Hamam Hadi, Susetyowati Susetyowati   +2 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source