Results 81 to 90 of about 611,994 (356)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Prediction of length of hospital stay

Comprehensive Psychiatry, 1972
Abstract The Missouri standard system of psychiatry 1 is a statewide program for reporting uniform information on all patients admitted to the hospitals within the Missouri Division of Mental Health. Professional staff, technicians, clerks, patients, and relatives contribute precoded observations about patients.
Marjorie L. Brown, Harold Altman, Hugh V. Angle, Ivan W. Sletten   +3 more
openaire   +3 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Analysis of the Literature on Emergency Department Throughput

Western Journal of Emergency Medicine, 2009
Introduction: The purpose of this paper was to review and analyze all the literature concerning ED patient throughput. The secondary goal was to determine if certain factors would significantly alter patients’ ED throughput.Methods: A MEDLINE search was ...
Zun, Leslie S
doaj  

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Length of Stay After Childbirth in 92 Countries and Associated Factors in 30 Low- and Middle-Income Countries: Compilation of Reported Data and a Cross-sectional Analysis from Nationally Representative Surveys

PLoS Medicine, 2016
Background Following childbirth, women need to stay sufficiently long in health facilities to receive adequate care. Little is known about length of stay following childbirth in low- and middle-income countries or its determinants.
O. Campbell, L. Cegolon, D. Macleod, Lenka Benova   +3 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Postpartum length of hospital stay among obstetric patients in Ibadan, Nigeria

BMC Health Services Research
Background Postpartum Length of hospital stay (PLOHS) is an essential indicator of the quality of maternal and perinatal healthcare services. Identifying the factors associated with PLOHS will inform targeted interventions to reduce unnecessary ...
Ikeola A. Adeoye, Blessing U. Aleka, Rotimi F. Afolabi, Timothy A.O Oluwasola   +3 more
doaj   +1 more source

Modifying the RAPT Score to Reflect Discharge Destination in Current Practice

Arthroplasty Today, 2021
Background: The Risk Assessment Prediction Tool (RAPT) is a validated 6-question survey designed to predict primary total joint arthroplasty (TJA) patients’ discharge disposition.
Eric Cohen, MD, Daniel B.C. Reid, MD, MPH, Matthew Quinn, MD, Devin Walsh, MD, Jeremy Raducha, MD, Leigh Hubbard, RN, MHA, John Froehlich, MD   +6 more
doaj  

Determining Influential Factors on the Length of Stay in the Southeast Hospitals of the Country before and after the Outbreak of the COVID-19 Pandemic [PDF]

تحقیقات سلامت در جامعه, 2023
Introduction and purpose: The spread of the COVID-19 disease and the increase in healthcare costs have made health care providers look for a solution to evaluate the performance of the healthcare delivery system.
Fatemeh BagherBarahouei, Mohammad Khammarnia, Alireza Ansarimoghadam   +2 more
doaj