Results 41 to 50 of about 1,156,270 (203)

Efficacy and safety of rufinamide in pediatric epilepsy

Therapeutic Advances in Neurological Disorders, 2013
Rufinamide is a novel anticonvulsant medication approved by the US Food and Drug Administration (FDA) in 2008 for the treatment of seizures associated with Lennox–Gastaut syndrome in patients 4 years of age and older, based upon clinical trials ...
David T. Hsieh, Elizabeth A. Thiele
doaj   +1 more source

Epilepsy in Christianson syndrome: Two cases of Lennox–Gastaut syndrome and a review of literature

Epilepsy & Behavior Reports, 2020
Christianson syndrome (CS) is an X-linked intellectual disorder caused by mutations in the SLC9A6 gene. Clinical features of CS include an inability to speak, truncal ataxia, postnatal microcephaly, hyperkinesis, and epilepsy. Almost all patients with CS
Azusa Ikeda, Ayako Yamamoto, Kazushi Ichikawa, Yu Tsuyusaki, Megumi Tsuji, Mizue Iai, Yumi Enomoto, Hiroaki Murakami, Kenji Kurosawa, Satoko Miyatake, Naomichi Matsumoto, Tomohide Goto   +11 more
doaj   +1 more source

Band Heterotopia and Lennox-Gastaut Syndrome: A Case Report

, 2018
Heterotopia, referred to as a limited or common neuronal migration disorder, may manifest clinically with mild mental retardation, epileptic seizures, psychiatric symptoms, or systemic disorders.
Mehmet Fatih GÖL, Füsun Ferda ERDOĞAN
core   +1 more source

Prognosis of Infantile Spasms and L-G Syndrome

Pediatric Neurology Briefs, 1999
The occurrence, outcome, and prognostic factors of infantile spasms (IS) and Lennox-Gastaut syndrome (LGS) were determined in children treated in the Department of Pediatrics, University of Oulu, Finland, from Jan 1976 to Dec 1993.
J Gordon Millichap
doaj   +1 more source

Facilitating the timely diagnosis of Lennox–Gastaut syndrome: A checklist to support clinical practice

Epileptic Disorders, EarlyView.
Abstract Objective To develop and evaluate a simple‐to‐use checklist to support physicians with the timely diagnosis of Lennox–Gastaut syndrome (LGS). Methods A panel of 10 pediatric and adult epileptologists used the International League Against Epilepsy (ILAE) criteria for LGS classification and definition to develop seven questions for the checklist,
Nicola Specchio, Alexis Arzimanoglou, Stéphane Auvin, Antonio Gil‐Nagel, Lieven Lagae, Rima Nabbout, Susanne Schubert‐Bast, Adam Strzelczyk, Eugen Trinka, J. Helen Cross   +9 more
wiley   +1 more source

Late-onset Lennox-Gastaut syndrome as a phenotype of 15q11.1q13.3 duplication [PDF]

, 2012
The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills and language development, cognitive and learning disabilities, autism spectrum ...
Guerra, C, Rosas, MJ, Oliveira, R, Ricardo Rego, Dória, S, Rego, R, Cátia Guerra, João Rocha, Renata Oliveira, Maria José Rosas, Rocha, J, Sofia Dória   +11 more
core   +3 more sources

Refining the electroclinical phenotype of 15q11.2 microdeletion: EEG biomarker overlap with Angelman syndrome

Epileptic Disorders, EarlyView.
Abstract The 15q11.2 microdeletion is a chromosomal condition associated with a broad epileptic phenotype. It is differentiated from Angelman syndrome, which is typically a larger maternal deletion in an overlapping area. We describe a patient with a 15q11.2 microdeletion that has clinical and EEG biomarker features similar to those seen in Angelman ...
Hok Leong Chin, Joshua Chang, Douglas Nordli III   +2 more
wiley   +1 more source

Expert Consensus on Clobazam in the Treatment of Refractory Epilepsy (2022)

Xiehe Yixue Zazhi, 2022
After regular anti-epileptic drug treatment, the symptoms of most patients with epilepsy can be well controlled or relieved, but 30%-40% of patients with epilepsy, after long-term drug treatment, still suffer from repeated seizures and develop refractory
Multi-disciplinary Team for Rare Diseases, Peking Union Medical College Hospital National Rare Diseases Committee
doaj   +1 more source

The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Epileptic Disorders, EarlyView.
Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity ...
Ionuț‐Flavius Bratu, Agnès Trébuchon, Fabrice Bartolomei   +2 more
wiley   +1 more source

Genetic testing among patients evaluated for epilepsy surgery

Epileptic Disorders, EarlyView.
Abstract Objective Genetic testing performed to identify the underlying etiology of epilepsy has become increasingly common and is now being recommended as part of the presurgical evaluation for epilepsy surgery. This study aimed to characterize the types of genetic tests performed in patients evaluated for epilepsy surgery and assess how genetic ...
Anni Saarela, Veera‐Julia Kuronen, Oskari Timonen, Leena Jutila, Katri Silvennoinen, Annemari Kilpeläinen, Jarkko Kirjavainen, Reetta Kälviäinen   +7 more
wiley   +1 more source