Results 71 to 80 of about 1,156,270 (203)
Oligogenic inheritance in epilepsy: A systematic exome‐wide analysis
Epilepsia, EarlyView.Abstract Objective Genetic factors contribute to the majority of epilepsies, but the exact genetic cause remains unknown in most patients. Incomplete penetrance and variable expressivity are frequent, and recent studies showed a burden of deleterious variants in epilepsy genes, suggesting a role for oligogenic inheritance.
Sarah Duerinckx +192 more
wiley +1 more source
Toxic Hepatitis in a Case of Angelman Syndrome Associated With Lennox-Gastaut Syndrome
, 2004 Kansu, Aydan/0000-0002-3133-9846Toxic hepatitis in a case of Angelman syndrome associated with Lennox-Gastaut syndrome: We report a 26-month-old boy with Angelman syndrome associated with Lennox-Gastaut syndrome, who developed a rash and a persistent ...
Girgin, N +6 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Use of neuromodulation strategies targeting thalamic nuclei, including deep brain stimulation (DBS) and responsive neurostimulation (RNS), for treatment of pediatric drug‐resistant epilepsy (DRE) is increasing, despite limited evidence for efficacy and safety. We present the initial results from the Comparative Multicenter Evaluation
Samuel A. Tenhoeve +28 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Lennox–Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy defined by polymorphic seizures, intellectual disability (ID), and characteristic electroencephalographic (EEG) patterns. The applicability and biological validity of current electroclinical criteria remain debated.
Emanuele Cerulli Irelli +12 more
wiley +1 more source
, 2009 Lennox-Gastaut syndrome is one of the most severe epileptic encephalopathies of childhood onset. The cause of this syndrome can be symptomatic (ie, secondary to an underlying brain disorder) or cryptogenic (ie, has no known cause).
Pellock JM +11 more
core +1 more source
Cannabidiol per al tractament de la síndrome de Lennox-Gastaut i la síndrome de Dravet [PDF]
, 2020 Epilèpsia; Cannabidiol; Síndrome Lennox-Gastaut; Síndrome DravetEpilepsia; Cannabidiol; Síndrome Lennox-Gastaut; Síndrome DravetEpilepsy; Cannabidiol; Lennox-Gastaut Syndrome; Dravet syndromeLes síndromes de Lennox-Gastaut (SLG) i de Dravet (SD) són ...
Programa d'Harmonització Farmacoterapèutica
core
Epilepsia, EarlyView.Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni +4 more
wiley +1 more source
Perils and progress in epilepsy surgery utilization: Twenty‐five years later
Epilepsia, EarlyView.Abstract More than 25 years have passed since the first randomized controlled trial (RCT) established that surgery is superior to continued anti‐seizure medication (ASM) for drug‐resistant temporal lobe epilepsy, and nearly as long since a joint practice parameter urged that appropriate surgical candidates be referred to a specialized center for ...
Dario J. Englot
wiley +1 more source
Lennox-gastaut Syndrome With Good Outcome Associated With Perisylvian Polymicrogyria
, 2015 This chapter showcases a patient suffering from Lennox-Gastaut syndrome due to perisylvian polymicrogyria. The 10-year-old right-handed boy had a history of dysarthria and seizures. He started having seizures at 3 years of age.
Guerreiro M.M.
core +1 more source
Epilepsia, EarlyView.Abstract Objective We assessed the timing, dosing, and effectiveness of diazepam nasal spray in a large dataset of seizures treated in the out‐of‐hospital setting, using as reference the International League Against Epilepsy criteria for tonic–clonic status epilepticus (SE) and its treatment.
John M. Stern +10 more
wiley +1 more source