Results 81 to 90 of about 1,156,270 (203)

Immunological disturbance in West and Lennox-Gastaut syndromes

Arquivos de Neuro-Psiquiatria, 1984
Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of Ô and  peripheral blood lymphocytes, serum levels of IgG, IgA and IgM ...
Terezinha C. B. Montelli, Norma G. S. Mota, M. Terezinha S. Peraçoli, Elza A. Torres, M. Thereza Rezkallah-Iwasso   +4 more
doaj   +1 more source

New antiepileptic drugs in the treatment of Lennox-Gastaut syndrome [PDF]

, 2010
Lennox–Gastaut syndrome is a childhood epileptic encephalopathy characterised by polymorphic seizures and neuropsychological decline. The most characteristic seizures are tonic fits, atypical absences and atonic seizures, in that order. Treatment options
COPPOLA, Giangennaro, G. COPPOLA, ALBERTO VERROTTI, HOW TO, CLAUDIA DEGIDIO, GIULIA LOIACONO, LUCIA FIORDALISO   +6 more
core  

Lennox-Gastaut syndrome and phenotype: Secondary network epilepsies

, 2014
OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a severe epilepsy phenotype with characteristic electroclinical features despite diverse etiologies. We previously found common cerebral networks involved during slow spike-and-wave (SSW) and generalized ...
Archer, JS, Stagnitti, MR, Warren, AEL, Jackson, GD, Abbott, DF, Masterton, RAJ   +5 more
core   +1 more source

A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants

Epilepsia, EarlyView.
Abstract This Phase I study evaluated the safety, tolerability, and pharmacokinetics of a 30‐min topiramate injection (intravenous [IV] TPM) infusion compared with oral topiramate (oral TPM) in healthy adult participants. In this randomized, open‐label, dose escalation, crossover study with 37 healthy participants received single doses of 50, 100, or ...
Adeboye O. Bamgboye, James C. Cloyd, Bernard D. King, Lisa D. Coles   +3 more
wiley   +1 more source

Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome [PDF]

Annals of Child Neurology
Purpose This study examined the characteristics and outcomes of resective epilepsy surgery following corpus callosotomy (CC) in children with Lennox-Gastaut syndrome (LGS).
Soyoung Park, Hye Eun Kwon, Chung Mo Koo, Yun Jung Hur, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim   +6 more
doaj   +1 more source

Revisiting the concept that interictal implies asymptomatic: Pulse wave amplitude drops uncover autonomic responses during generalized paroxysmal fast activities

Epilepsia, EarlyView.
Abstract Objective Interictal electroencephalographic (EEG) activities are generally considered asymptomatic. Pulse wave amplitude drop (PWAD) is a marker of autonomic nervous system (ANS) reactivity linked to cardiovascular risk. Generalized paroxysmal fast activity (GPFA) is a major EEG pattern in different epileptic conditions.
Julie Lévi‐Strauss, Valerio Frazzini, Claude Adam, Isabelle Gourfinkel‐An, Sophie Dupont, Vincent Navarro, Vi‐Huong Nguyen‐Michel   +6 more
wiley   +1 more source

Programming of deep brain stimulation of the centromedian nucleus of the thalamus for drug‐resistant epilepsy: A meta‐analysis and proposed programming framework

Epilepsia, EarlyView.
Abstract Objective Although the centromedian nucleus of the thalamus (CM) is an increasingly considered deep brain stimulation (DBS) target for drug‐resistant epilepsy (DRE), there is significant variability in programming practices, which may contribute to heterogenous outcomes.
Mohammed A. AlQahtani, Michal Stern‐Zimmer, Puneet Jain, Suvasini Sharma, Alfonso Fasano, Alexander Rotenberg, George M. Ibrahim, Carolina Gorodetsky   +7 more
wiley   +1 more source

Lamotrigine (Lamictal) in Intractable Epilepsies

Pediatric Neurology Briefs, 1997
The efficacy of lamotrigine (LTG) in an open, add-on, prospective study of 56 children with refractory generalized epilepsies is reported from British Columbia’s Children’s Hospital, Vancouver, BC, Canada.
J Gordon Millichap
doaj   +1 more source

Phenotypic and transcriptomic characterization of biallelic RNU2‐2 developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective A significant proportion of individuals with suspected genetic developmental and epileptic encephalopathies (DEEs) remain unsolved following whole genome sequencing (WGS). Here we describe biallelic RNU2‐2 variants causing a recently reported, severe, recessive DEE.
Olivia J. Henry, Nadja Pekkola Pacheco, Irene Duba, Magnus Burstedt, Daniel Carlberg, Angelica M. Delgado‐Vega, Anna Hammarsjö, Sofie Ivarsson, Tord Jonson, Kristina Karrman, Nicole Lesko, Åsa Lindfors, Daniel Nilsson, Mia Olsson Engman, Lucía Peña‐Pérez, Erik Stenund, Fulya Taylan, Malin Ueberschär, Samuel Wiafe, Sofia Ygberg, Anna Lindstrand, Anna Wedell, Ann Nordgren, Tommy Stödberg   +23 more
wiley   +1 more source

Psychoses and Epilepsy: Paradoxical Normalization

Pediatric Neurology Briefs, 1994
Five children aged 2.5 to 9 years who developed paradoxical, or forced normalization (acute psychiatric symptoms with abrupt cessation of seizures and normalized EEG) are reported from the Shaare Zedek Medical Center, Jerusalem.
J Gordon Millichap
doaj   +1 more source