Results 41 to 50 of about 1,022,216 (261)

Visual performance with changes in eccentricity in PROSE device: A case report

Journal of Optometry, 2014
This case report describes the variations in visual performance of a subject with moderate keratoconus with changes in front surface eccentricities (FSEs) of PROSE (Prosthetic Replacement of Ocular Surface Ecosystem).
Divya Jagadeesh, Rajeswari Mahadevan
doaj   +1 more source

REVIEW: Truly critical and honest appraisals of The Guardian’s record as a guardian of power still needed

Pacific Journalism Review, 2021
Capitalism’s Conscience: 200 Years of the Guardian, edited by Des Freedman. London: Pluto Press. 2021, 320 pages. ISBN 9780745343341; 9780745343358 A collection of essays, Capitalism’s Conscience—200 Years of the Guardian, has been recently published.
David Edwards
doaj   +1 more source

The Influence of extracellular matrix on lens epithelial cell viability [PDF]

, 2006
Posterior capsular opacification is the main complication of cataract surgery and results from the proliferation, migration and differentiation of lens epithelial cells remaining in the capsular bag. To better understand this pathological cell behaviour,
Frederique, M D Tholozan, Frederique, M.D. Tholozan   +1 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Evaluating pathological levels of intracellular cholesterol through Raman and surface-enhanced Raman spectroscopies

Scientific Reports
Versatile methods for the quantification of intracellular cholesterol are essential for understanding cellular physiology and for diagnosing disorders linked to cholesterol metabolism.
Enrico Baria, Caterina Dallari, Francesco Mattii, Francesco Saverio Pavone, Caterina Credi, Riccardo Cicchi, Amelia Morrone, Claudia Capitini, Martino Calamai   +8 more
doaj   +1 more source

Scleral contact lens thickness profiles: The relationship between average and centre lens thickness

, 2019
Purpose To develop a methodology to reliably determine the thickness profile of scleral contact lenses and examine the relationship between the centre and average lens thickness for a range of lens designs and back vertex powers.
David Alonso-Caneiro, Stephen J. Vincent, Alonso-Caneiro, David, Henry Kricancic, Michael J. Collins, Kricancic, Henry, Vincent, Stephen J, Collins, Michael J   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Time course of corneal oxygen uptake during contact lens wear [PDF]

, 1988
We used a polarographic oxygen sensor to measure corneal oxygen uptake rates of 16 subjects during daily wear of soft contact lenses. The subjects reported for examinations on nine occasions over a 30-week lens wearing period. Corneal oxygen uptake rates
Carney, Leo G., Brennan, Noel A.
core  

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. [PDF]

, 2013
Pax6 encodes a specific DNA-binding transcription factor that regulates the development of multiple organs, including the eye, brain and pancreas. Previous studies have shown that Pax6 regulates the entire process of ocular lens development.
Tessa Walcher, Jovica Ninkovic (104237), David C Beebe, Deyou Zheng (7943), Ying Yang (24175), Xie, Q., Jie Huang, Louise Wolf (104240), Ariel Vitenzon (104242), Vitenzon, Ariel, Magdalena Götz, Zavadil, J., Wolf, L., Deyou Zheng, Götz, M., Yang, Ying, Ales Cvekl, Wolf, Louise, Tessa Walcher (104238), Yang, Y., Cvekl, A., Zheng, D.Y., Louise Wolf, Ninkovic, J., Jovica Ninkovic, Ariel Vitenzon, Götz, Magdalena, Jiri Zavadil (10270), Walcher, Tessa, Magdalena Götz (32199), Zavadil, Jiri, Qing Xie, Ninkovic, Jovica, Walcher, T., David C. Beebe (104247), Beebe, D.C., Zheng, Deyou, Huang, Jie, Cvekl, Ales, David C. Beebe, Xie, Qing, Jie Huang (104235), Ales Cvekl (104250), Vitenzon, A., Beebe, David C., Qing Xie (104232), Ying Yang, Jiri Zavadil, Huang, J., Xie Qing, Wolf Louise, Huang Jie, Walcher Tessa, Götz Magdalena, Cvekl Ales, Zheng Deyou, Vitenzon Ariel, Beebe David C., Yang Ying, Ninkovic Jovica, Zavadil Jiri   +60 more
core   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source