Results 191 to 200 of about 116,783 (314)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells. [PDF]

Sci Rep, 2020
Olender L, Bujanover N, Sharabi O, Goldstein O, Gazit R.   +4 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Protocol for the simultaneous activation and lentiviral transduction of primary human T cells with artificial T cell receptors. [PDF]

STAR Protoc
Tan JYM, Tan JC, Wang C, Wu L, Gascoigne NRJ, Bhatt S.   +5 more
europepmc   +1 more source

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources. [PDF]

J Immunother Cancer, 2020
Schmidts A, Marsh LC, Srivastava AA, Bouffard AA, Boroughs AC, Scarfò I, Larson RC, Bedoya F, Choi BD, Frigault MJ, Bailey SR, Leick MB, Vatsa S, Kann MC, Prew MS, Kleinstiver BP, Joung JK, Maus MV.   +17 more
europepmc   +1 more source

Lentiviral Based Gene Transduction and Promoter Studies in Human Hematopoietic Stem Cells (hHSCs)

, 2011
Nadimpalli R. S. Varma, Branislava Janic, Mudasir Ali, Asm Iskander, Ahmadreza Arbab   +4 more
openalex   +1 more source

No Impact of Lentiviral Transduction on Hematopoietic Stem/Progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model [PDF]

, 2013
Stephanie Sellers, Bogdan Dumitriu, Mary J. Morgan, William M. Hughes, Colin O. Wu, Nalini Raghavarchari, Yanqin Yang, Naoya Uchida, John F. Tisdale, Dong Sung An, Irvin S. Y. Chen, Peiman Hematti, Robert E. Donahue, André Larochelle, Neal S. Young, Rodrigo T. Calado, Cynthia E. Dunbar   +16 more
openalex   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

HBV-Specific TCR-T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation. [PDF]

Clin Cancer Res
Zhao Q, Huang J, Luo W, Tan H, Wong RWJ, Liu Z, Qin M, Li J, Koh S, Wai LE, Wang T, Dan J, Guo Z, He X.   +13 more
europepmc   +1 more source

Construction of a Single Lentiviral Vector Containing Tetracycline-Inducible Alb-uPA for Transduction of uPA Expression in Murine Hepatocytes

, 2013
Jia-si Bai, Jungang Li, Qing Mao
openalex   +2 more sources