Results 191 to 200 of about 1,111,723 (286)

Challenges in lentiviral vector production: retro-transduction of producer cell lines. [PDF]

Front Bioeng Biotechnol
Klimpel M, Obert C, Terrao M, Singh P, Wei H, Chen CG, Gille A, Wissing S, Laux H.   +8 more
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production. [PDF]

Mol Ther Methods Clin Dev
Nogueira RJ, Rodrigues AF, Mestre DA, Coroadinha AS.   +3 more
europepmc   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Development of a Lentiviral Vector for High-Yield Production of Synthetic and Recombinant GCase for Gaucher Disease Therapy. [PDF]

Int J Mol Sci
Coelho AC, Wiezel CEV, de Campos AC, Figueiredo LLS, Suardi GAM, de Paula Bernardes J, da Cunha Tirapelli DP, Faça VM, Abraham KJ, Carlotti-Júnior CG, Siciliano V, Weiss R, Gerson S, Fontes AM.   +13 more
europepmc   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes. [PDF]

Nat Commun
Canepari C, Milani M, Simoni C, Starinieri F, Volpin M, Fabiano A, Biffi M, Russo F, Norata R, Rocchi M, Brombin C, Cugnata F, Montini E, Sanvito F, Grompe M, Cantore A.   +15 more
europepmc   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vector. [PDF]

Mol Ther
Coradin T, Keating AL, Barnard AR, Whilding L, Pombal D, Hannoun Z, Lewis J, Devarajan G, Iqball S, Burton E, Ferluga S, Jones DM, Alberts BM, Wright J, Farley DC, O'Connor DM, Rao RM, Mitrophanous KA, Lad Y, Nimmo R.   +19 more
europepmc   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source