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Lentiviral Vectors as a Vaccine Platform against Infectious Diseases
Pharmaceutics, 2023 Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing dendritic cells in vivo. Within these cells, which are the most
Kirill Nemirov +5 more
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Special Issue “Lentiviral Vectors”
Viruses, 2022 Lentiviral vectors (LV) have been developed upon knowledge accumulated in the virology field, in particular intensive research on HIV biology since its discovery in 1983 [...]
Yasuhiro Takeuchi
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Lentiviral Vector Bioprocessing [PDF]
Viruses, 2021 Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian cells and are now commonly utilised within the growing field of cell and gene therapy for the treatment of monogenic diseases and adoptive therapies such as chimeric antigen T-cell (CAR-T) therapy.
Andrea C M E Rayat
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Production of lentiviral vectors
Molecular Therapy: Methods & Clinical Development, 2016 Lentiviral vectors (LV) have seen considerably increase in use as gene therapy vectors for the treatment of acquired and inherited diseases. This review presents the state of the art of the production of these vectors with particular emphasis on their ...
Otto-Wilhelm Merten +2 more
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Advances of Lentiviral Vectors
Chinese Journal of Lung Cancer, 2014 Lentiviral vectors are currently very effective tools in molecular and cell experiment. Lentiviral vector, a kind of retroviral vectors, has a number of unique advantages in target gene transferation, for example, the ability of transfection to the ...
Fanrong MENG +3 more
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HIV-based lentiviral vectors: Origin and sequence differences
Molecular Therapy: Methods & Clinical Development, 2021 Three gene therapy strategies have received US Food and Drug Administration (FDA) approval; one includes HIV-1-based lentiviral vectors. These vectors incorporate features to provide long-term gene transfer and expression while minimizing generation of a
Nathan M. Johnson +5 more
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Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
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The Old and the New: Prospects for Non-Integrating Lentiviral Vector Technology
Viruses, 2020 Lentiviral vectors have been developed and used in multiple gene and cell therapy applications. One of their main advantages over other vectors is the ability to integrate the genetic material into the genome of the host.
Luis Apolonia
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Integrase deficient lentiviral vector: prospects for safe clinical applications [PDF]
PeerJ, 2022 HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new ...
Chee-Hong Takahiro Yew +6 more
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Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine. [PDF]
PLoS ONE, 2008 Lentiviral vectors are under intense scrutiny as unique candidate viral vector vaccines against tumor and aggressive pathogens because of their ability to initiate potent and durable specific immune responses.
Frédéric Coutant +3 more
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