Lentiviral Vectors for Ocular Gene Therapy [PDF]
Pharmaceutics, 2022 This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, and an overview of their use in the field of ophthalmology.
Yvan Arsenijevic +3 more
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Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. [PDF]
PLoS ONE, 2009 BACKGROUND: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Peter C Huszthy +7 more
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Design and Potential of Non-Integrating Lentiviral Vectors
Biomedicines, 2014 Lentiviral vectors have demonstrated promising results in clinical trials that target cells of the hematopoietic system. For these applications, they are the vectors of choice since they provide stable integration into cells that will undergo extensive ...
Aaron Shaw, Kenneth Cornetta
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Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants [PDF]
BMC Biotechnology, 2009 Background Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in ...
Rosenqvist Nina +3 more
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The Inside Out of Lentiviral Vectors
Viruses, 2011 Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene ...
Stéphanie Durand, Andrea Cimarelli
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Effects of an indole derivative on cell proliferation, transfection, and alternative splicing in production of lentiviral vectors by transient co-transfection. [PDF]
PLoS ONELentiviral vectors derived from human immunodeficiency virus type I are widely used to deliver functional gene copies to mammalian cells for research and gene therapies.
Nataly Carolina Mier, Donald Keith Roper
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Long-term stability of clinical-grade lentiviral vectors for cell therapy [PDF]
Molecular Therapy: Methods & Clinical DevelopmentThe use of lentiviral vectors in cell and gene therapy is steadily increasing, both in commercial and investigational therapies. Although existing data increasingly support the usefulness and safety of clinical-grade lentiviral vectors used in cell ...
Julie K. Jadlowsky +18 more
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Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media
Molecular Therapy: Methods & Clinical Development, 2020 Lentiviral vectors are increasingly utilized in cell and gene therapy applications because they efficiently transduce target cells such as hematopoietic stem cells and T cells.
Matthew Bauler +12 more
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Process intensification for lentiviral vector manufacturing using tangential flow depth filtration
Molecular Therapy: Methods & Clinical Development, 2023 For gene therapies to become more accessible and affordable treatment options, process intensification is one possible strategy to increase the number of doses generated per batch of viral vector.
Robert M. Tona +6 more
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Improved SARS-CoV-2 Spike Glycoproteins for Pseudotyping Lentiviral Vectors
Frontiers in Virology, 2021 The spike (S) glycoprotein of SARS-Cov-2 facilitates viral entry into target cells via the cell surface receptor angiotensin-converting enzyme 2 (ACE2).
Paul G. Ayoub +15 more
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