Results 51 to 60 of about 87,400 (287)

Observation of single adenovirus or lentivirus co-infected 293A cells.

, 2013
Ad5 control indicates the amount of 104, 105 and 106 infectious units (IFU) of Ad5 alone infected 293A cells; LV-CMV-IFNγ+Ad5 and LV-CMV-GFP+Ad5 indicate the number of 108 copies of LV-CMV-IFNγ or LV-CMV-GFP co-infected 293A cells with the amount of 104,
Yunceng Weng (311260), Lifang Shuai (311262), Jean-Pierre Allain (255856), Sen Yin (311258), Chengyao Li (311264), Jianhua Zhou (311263), Junwen Shi (311261), Wanlong Tan (311259), Dong Xiao (162830), Wenjing Wang (181404), Tingting Li (10553), Ling Zhang (18071), Hongwei Li (17402)   +12 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Seropositivity for Maedi-Visna virus in sheep in Porto Acre city – Western Amazon, Brazil

Ciência Animal Brasileira, 2020
Lentivirosis of small ruminants (LVPR) are chronic and degenerative infectious diseases, caused by Lentivirus, associated with numerous losses such as: drop in meat and milk production, predisposition to secondary infections, expenses with veterinary ...
Karolyne Teixeira Vinha, Tamyres Izarelly Barbosa da Silva   +1 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery

, 2003
Copyright © 2003 by American Society of HematologyCyclic neutropenia is a rare disease that occurs both in humans and gray collie dogs and is characterized by recurrent severe neutropenia leading to bacterial infections and shortened life expectancy ...
Katen, L., Flint, L., Osborne, W., Christensen, J., Liggitt, D., Barry, S., Yanay, O., Brzezinski, M., Dale, D.   +8 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Seroprevalence Survey of Maedi-Visna Among Twenty-Four Ovine Floks from Twelve Regions of China

Journal of Integrative Agriculture, 2013
Maedi-visna virus (MVV) is an ovine lentivirus that is widespread in many countries worldwide. Both clinical and subclinical MVV infections cause substantial economic losses.
Ke-shan ZHANG, Ji-jun HE, Yong-jie LIU, You-jun SHANG, Xiang-tao LIU   +4 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

CRISPR/Cas9 as a therapeutic tool for triple negative breast cancer: from bench to clinics

Frontiers in Molecular Biosciences, 2023
Clustered regularly interspaced short palindromic repeats (CRISPR) is a third-generation genome editing method that has revolutionized the world with its high throughput results.
Prashant Kumar Tiwari, Tin-Hsien Ko, Rajni Dubey, Mandeep Chouhan, Lung-Wen Tsai, Lung-Wen Tsai, Lung-Wen Tsai, Himanshu Narayan Singh, Kundan Kumar Chaubey, Deen Dayal, Chih-Wei Chiang, Chih-Wei Chiang, Sanjay Kumar   +12 more
doaj   +1 more source