Results 91 to 100 of about 62,168 (302)

Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment

mBio, 2016
There has been extraordinary progress in understanding the roles of lentiviral accessory proteins in antagonizing host antiviral defense proteins. However, the precise primary function of the accessory gene Vpr remains elusive.
Oliver I. Fregoso, Michael Emerman
doaj   +1 more source

RNA packaging in lentiviruses [PDF]

Retrovirology, 2009
The selection by a lentivirus of its genomic RNA from the background of a vast excess of cellular messenger RNAs and sub-genomic viral RNAs occurs with high specificity. The nature and site of the specific interaction between the unspliced RNA genome and the gag polyprotein, which is responsible for its capture, is still poorly understood and the ...
openaire   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Cell-fate determination by ubiquitin-dependent regulation of translation. [PDF]

, 2015
Metazoan development depends on the accurate execution of differentiation programs that allow pluripotent stem cells to adopt specific fates. Differentiation requires changes to chromatin architecture and transcriptional networks, yet whether other ...
Fedrigo, Indro, Ingolia, Nicholas T, Iwasaki, Shintaro, McGourty, Colleen A, Medina-Ruiz, Sofia, Rape, Michael, Teerikorpi, Nia, Werner, Achim   +7 more
core   +1 more source

A Novel Dual Lentiviral CRISPR-based Transcriptional Activation System for Gene Expression Regulation in Neurons

Bio-Protocol, 2019
Robust and efficient gene expression control enables the study of a gene’s function in the central nervous system. Advances in CRISPR-based technology provide new avenues not only for gene editing, but for complex transcriptional control.
Katherine Savell, Faraz Sultan, Jeremy Day   +2 more
doaj   +1 more source

A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat

mBio, 2020
Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2.
James H. Morrison, Caitlin Miller, Laura Bankers, Gary Crameri, Lin-Fa Wang, Eric M. Poeschla   +5 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Anti-tetherin activities in Vpu-expressing primate lentiviruses

Retrovirology, 2010
Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells.
Haworth Kevin G, Exline Colin M, Hauser Heiko, Lopez Lisa A, Yang Su, Cannon Paula M   +5 more
doaj   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55GAG) of the virion nucleocapsid proteins [PDF]

, 2009
The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis. Using an in vivo mammalian two-hybrid assay, the interaction between Vif and the precursor (Pr55GAG) of the virion ...
A Harmache, A Mehle, AM Borman, AM Sheehy, AM Sheehy, B Liu, B Liu, B Mangeat, C Tian, DH Gabuzda, DH Gabuzda, Farhatullah Syed, H Ochman, H Zhang, HA Vasavada, I Sadowski, JH Simon, K Luo, K Stopak, L Baraz, L Fan, M Bouyac, M Bouyac, M Boyce, M Marin, MA Adekale, Malcolm A. McCrae, MS Oberste, N Madani, RA Fouchier, RC Desrosiers, RS Harris, S Cen, S Erickson-Viitanen, S Hoglund, SG Conticello, SK Arya, TH Lee, X Yu, Y Gluzman, Y Imai, Y Yu, YH Zheng   +42 more
core   +1 more source