Results 101 to 110 of about 46,404 (214)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Engineering a DYRK1B R102C mutation: insights into metabolic syndrome pathogenesis through lentiviral gene delivery [PDF]

Medical Laboratory Journal
Background: A rare heterozygous DYRK1B mutation (R102C) recently linked to a familial form of metabolic syndrome prompted this study to introduce the R102C mutation into the mouse DYRK1B gene, utilizing recombinant lentiviruses for long-term gene ...
Afrooz Daneshparvar, Iman Jamhiri, Vahid Razban, Jafar Fallahi, Nasrin Hamidizadeh, Behnam Moghtaderi, Mehdi Dianatpour   +6 more
doaj  

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, EarlyView.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang, Xingtao Zhou, Xujie Wang, Mingyong Xie   +3 more
wiley   +1 more source

Single‐Cell CRISPR: An Efficient Strategy for Decoding Plant Cis‐Regulatory Complexity

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4454-4467, July 2026.
ABSTRACT The generation of complex traits involves the coordinated interplay of multiple gene networks. Elucidating the function of transcriptional cis‐regulatory elements (CREs) in regulating gene expression is crucial for understanding complex regulatory pathways and improving our ability to modify macro‐phenotypes.
Yuanhang Zhang, Xuanxuan Luo, Hongbin Li, Shuangxia Jin, Xianlong Zhang, Maojun Wang   +5 more
wiley   +1 more source

Encapsulin‐Protected Immunotherapeutic Complexes: Bacteria‐Derived Nanoparticles for mRNA Delivery to Eukaryotic Cells

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Here, we introduce a biological, self‐assembling supramolecular nanoparticle designed to encapsulate eukaryotic‐expressible mRNA within an encapsulin shell via an encapsulin‐RNA adaptor peptide (ERAP). This process occurs in bacteria, and the resulting complex can deliver its mRNA into eukaryotic cells, where it is expressed.
Carlos Francisco Coffeen, Maribel Cayetano‐Cruz, Damaris Ilhuicatzi‐Alvarado, Carmen Méndez, Leticia Moreno‐Fierros, Ismael Bustos‐Jaimes   +5 more
wiley   +1 more source

Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells. [PDF]

Stem Cell Reports
Zhang K, Liang H, Chen S.
europepmc   +1 more source

Sirt1 transgene delivery improves diabetes-impaired wound healing. [PDF]

Bioact Mater
Luo R, Wang H, Duan C, Jen M, Kuo HY, Wang X, Mrksich M, Ameer G.   +7 more
europepmc   +1 more source