Results 91 to 100 of about 51,346 (240)
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Arquivos do Instituto BiológicoObjetivou-se estudar a influência da artrite encefalite caprina no hemograma de cabras durante a lactação. Para tanto, 38 matrizes F1 Anglo-Nubiana x Saanen, com idade entre 14 e 38 meses e escore corporal entre dois e três, foram previamente testadas ...
R.P. Dias +6 more
doaj
Argonaute 2 restored erectile function and corpus cavernosum mitochondrial function by reducing apoptosis in a mouse model of cavernous nerve injury [PDF]
Investigative and Clinical UrologyPurpose: To determine whether the overexpression of the Argonaute RNA-induced silencing complex catalytic component 2 (Ago2) improves erectile function in mice after cavernous nerve injury (CNI).
Yan Huang +6 more
doaj +1 more source
, 2014 A) Correlation between the number of viral RNA molecules from five lentiviruses from different vectors (1. pLEX-EGFP-iCL, 2. pLEX-EGFP-iPuro, 3 pLEG-EGFP-iCL-shRNA(p53), 4. pLEG-EGFP- iPuro, 5. pLEG-EGFP-iPuro-shRNA(p53), all coding for the EGFP protein,
Benjamin Geiling (469741) +2 more
core +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
Advanced Science, EarlyView.In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
The Nef activity on HIV-1 infectivity
Frontiers in Microbiology, 2014 The replication and pathogenicity of lentiviruses is crucially modulated by auxiliary proteins which are expressed in addition to the canonical retroviral ORFs gag, pol and env.
Stéphane eBasmaciogullari +2 more
doaj +1 more source
Prevalência da infecção por lentivírus de pequenos ruminantes em caprinos em Teresina, Piauí
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2011 The prevalence of anti-lentiviruses antibodies of small ruminants was investigated in goat herds in the city of Teresina, PI, Brazil. A seroepidemiological survey was conducted involving 480 animals, apparently healthy, belonging to six rural properties.
A. Sampaio Júnior +5 more
doaj +1 more source
Advanced Science, EarlyView.Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen +13 more
wiley +1 more source
Diagnostic tools of small ruminant lentiviruses: standardization of indirect ELISA
, 2014 The Small Ruminant Lentiviruses (SRLVs) include Maedi-Visna (MV) of sheep and Caprine Arthritis-Encephalitis (CAE). These diseases are widespread and responsible for major production losses regarding sheep and goats.
Ricardo Abílio Bezerra e Silva (6124433) +7 more
core +1 more source