Results 201 to 210 of about 62,168 (302)

Immune Microenvironment Dynamics and Therapeutic Targets in GIST Revealed by Multi‐Omics and Functional Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT The tumour immune microenvironment (TIME) significantly influences the progression and treatment response of gastrointestinal stromal tumours (GIST), but the causal mechanisms and therapeutic targets remain incompletely understood. We integrated multi‐omics analyses, including Mendelian randomization analysis of 731 immune cell phenotypes to ...
Xingyuan Li, Jun Xiang, Zewen Chang, Qingchao Tang   +3 more
wiley   +1 more source

FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth. [PDF]

J Clin Invest
Gao J, Qing J, Li X, Luo Y, Huang L, Li H, Zhang H, Zhang J, Xiao P, Li J, Li T, He S.   +11 more
europepmc   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

CAPG Regulates Doxorubicin Resistance in Hepatocellular Carcinoma Cells via TGFB1/Smad/Nrf2 Signalling Pathway. [PDF]

J Cell Mol Med
Shang Y, Zhang J, Liu T.
europepmc   +1 more source

Cell and Gene Therapy in Equine Ocular Disease

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young, Lauren V. Schnabel, Brian C. Gilger   +2 more
wiley   +1 more source

The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication. [PDF]

PLoS Pathog
Lan Q, Zhang X, Sun Y, Yang J, Li X, Kuang E.   +5 more
europepmc   +1 more source

Inhibiting the Arp2/3 Complex Limits Infection of Both Intracellular Mature Vaccinia Virus and Primate Lentiviruses

, 2004
Jun Komano, Kosuke Miyauchi, Zene Matsuda, Naoki Yamamoto   +3 more
openalex   +2 more sources

miR-199a functions downstream of MeCP2 in neurons of <i>MECP2</i> duplication syndrome models. [PDF]

iScience
Akaba Y, Takahashi S, Adachi S, Nishimura M, Suzuki K, Nakashima H, Nakashima K, Kira R, Chong PF, Sakai Y, Hayashi Y, Kushima I, Mori D, Arioka Y, Okumura H, Nakayama A, Mizuno S, Yamamoto T, Osakada F, Ozaki N, Tsujimura K.   +20 more
europepmc   +1 more source

Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations. [PDF]

J Immunother Cancer
Rommel PC, Engel NW, Malachowski JK, Shukla D, Hodson IR, Gonzales D, van der Loo JCM, Young RM, Riley JL, Levine BL, June CH.   +10 more
europepmc   +1 more source

Sodium dodecyl sulfate as a viral inactivator and future perspectives in the control of small ruminant lentiviruses

, 2019
Ana Lídia Madeira de Sousa, R. R. Pinheiro, Juscilânia Furtado Araújo, Dalva Alana Aragão de Azevedo, Renato Mesquita Peixoto, A. Andrioli, Sabrina Tainah da Cruz Silva Bezerra, Maria Fátima da Silva Teixeira   +7 more
openalex   +1 more source