Results 191 to 200 of about 51,346 (240)

JMJD3 regulates the M2-like macrophage polarization and promotes the growth of breast cancer cells via STAT6/IRF4 axis. [PDF]

PLoS One
Lyu J, Wang E, Lyu S, Qian Y, Ye F, Xu X, Wang Q, Lu T, Hu L, Xu H, Zhang L.   +10 more
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Macrophage-Derived Extracellular Vesicles Deliver Progranulin to Alleviate Skin Wound Fibrosis. [PDF]

FASEB J
Huang X, Chen C, Liu X, Zhao C, Li Z, Dong G, Li S.   +6 more
europepmc   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, Volume 59, Issue 9, September 2026.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

<b>Gut microbiota butyrate mediated RUNX3 promotes Nr4a1</b>^<b>high</b><b>ZFP36</b>^<b>high</b> <b>resident macrophages via NR4A1/ERK1/2 MAPK to maintain gut homeostasis</b>. [PDF]

Gut Microbes
Gao Y, Shi Y, Zhu N, Hao Y, Wang J, Zhang Y, Yang R.   +6 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, Volume 117, Issue 3, Page 642-652, September 2026.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

In vivo chemogenetic RNA editing of macrophages by bioengineered viruses for sepsis treatment. [PDF]

Nat Commun
Xi W, Xu Y, Bao W, Ding Z, Xiao H, Yang J, Yan X, Ping Y.   +7 more
europepmc   +1 more source

SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Metastatic colon cancer remains a significant clinical challenge, often associated with poor patient prognosis. Recent studies have identified the secreted frizzled‐related protein 2 (SFRP2) as a key player in this malignancy, showing its overexpression in metastatic cases.
Yanshen Kuang, Xin Liu, Mu Ke, Zhijie Chang, Baoqing Jia, Bing Li, Honggang Qian   +6 more
wiley   +1 more source

The p.R249W Mutation in <i>LMNA</i>-Related Congenital Muscular Dystrophy Causes Nuclear Deformities and an Enrichment in Lamin A/C at the Ends of the Nucleus. [PDF]

Cells
Harvey C, Zhu Z, Han I, Cao K.
europepmc   +1 more source

Targeting the KIFC1‐SRSF3‐PKM Axis Suppresses Cervical Cancer Glycolysis and Enhances Radiosensitivity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Metabolic reprogramming towards enhanced glycolysis contributes to cervical cancer progression and radioresistance, but its upstream regulatory mechanisms remain poorly understood. Here, we investigated the role and underlying mechanisms of kinesin family member C1 (KIFC1) in glycolytic reprogramming and radiosensitivity in cervical cancer ...
Junxia Liu, Jiahao Li, Haiting Zhou, Wentao Ha, Xinyu Wu, Xiangdong Liu, Yizhi Jiang, Chen Gong, Yi Cheng, Qingxu Liu, Tengfei Chao, Huihua Xiong   +11 more
wiley   +1 more source