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The Lentiviruses of Sheep and Goats
1993The animal lentiviruses are nononcogenic, replication competent, and horizontally transmitted retroviruses (Narayan and Clements, 1989; see also Volume 1, Chapter 2). Each virus causes natural infection only in closely related species of animals. Based on host specificity, the viruses can be subdivided into families that cause infection in equidae ...
Opendra Narayan +8 more
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Immune evasion strategies of the primate lentiviruses
Immunological Reviews, 2001Summary: Individuals infected with human immunodeficiency virus (HIV) and macaques infected with simian immunodeficiency virus (SIV) make vigorous virus‐specific antibody and cellular immune responses. Despite these responses, virus replication continues at all stages of infection and ultimately leads to immunological collapse, onset of opportunistic ...
D T, Evans, R C, Desrosiers
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Nature Genetics, 2000
The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence efficiency of gene delivery.
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The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence efficiency of gene delivery.
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HIV-Related Lentiviruses of Nonhuman Primates
AIDS Research and Human Retroviruses, 1989The purpose of this review is to summarize the current status of known natural infections with SIV, the pathogenic potential of SIV in natural and unnaturual hosts, the genetic diversity of SIV, and possible monkey origins for HIV. In addition, we discuss the importance of SIV for studying the pathogenesis of AIDS and strategies for therapeutic and ...
R C, Desrosiers, M D, Daniel, Y, Li
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A Comparison of Regulatory Features in Primate Lentiviruses
AIDS Research and Human Retroviruses, 1992Historically, research into the regulation of gene expression in primate lentiviruses has focused on human immunodeficiency virus type 1 (HIV-1), the primary cause of acquired immunodeficiency syndrome (AIDS) in humans. The increasing emergence of HIV-2 as a human pathogen, and the importance of the various simian immunodeficiency viruses (SIV) as ...
B R, Cullen, E D, Garrett
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Lentiviruses to the placental rescue
Nature Biotechnology, 2007Lentiviral infection of mouse blastocysts allows specific transduction of the trophectoderm and its extra-embryonic derivatives.
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Blood, 2002
Lineage-specific and high-level expression of transgenes introduced into hematopoietic stem cells have been the holy grail of gene therapy for over a decade. Initial excitement and competitiveness to be first quickly faded into frustration and disappointment as 2 major hurdles were identified ...
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Lineage-specific and high-level expression of transgenes introduced into hematopoietic stem cells have been the holy grail of gene therapy for over a decade. Initial excitement and competitiveness to be first quickly faded into frustration and disappointment as 2 major hurdles were identified ...
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Small Ruminant Lentiviruses and Caseous Lymphadenitis
Veterinary Clinics of North America: Food Animal PracticeOvine progressive pneumonia and caprine arthritis encephalitis together are referred to as small ruminant lentiviruses (SRLVs). Along with caseous lymphadenitis (CL), SRLV are 2 of the so-called "iceberg diseases" of sheep and goats. In the case of SRLV, healthy tissue can be replaced with unproductive lymphoid tissue causing loss of milk, poor growth ...
Holly J, Neaton, Cindy, Wolf
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The comparative pathology of the lentiviruses
Journal of Comparative Pathology, 1998R S, Campbell, W F, Robinson
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Worldwide Prevalence of Small Ruminant Lentiviruses in Sheep: A Systematic Review and Meta-Analysis
Animals, 2021Estela Perez, Hector Ruiz, M Perez
exaly