Results 171 to 180 of about 51,346 (240)

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li   +5 more
wiley   +1 more source

Development and Application of a Pseudovirus-Based Assay for Modelling SARS-CoV-2 Spike Protein Mediated Drug Screening. [PDF]

Int J Mol Sci
Khasanov SA, Esaulkova IL, Volobueva AS, Slita AV, Kriger DV, Tentler D, Yarovaya OI, Sokolova AS, Gorshkov AN, Dolgova AS, Lavrentieva IN, Dedkov VG, Salakhutdinov NF, Zarubaev VV.   +13 more
europepmc   +1 more source

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Under conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Xiaoming Liu, Wenyu Zhang, Hang Feng, Linying Lai, Chen Cao, Guang Yang, Yanzheng Gao, Bijun Wang, Hui Wang, Bin Yu, Zhenghong Yu   +10 more
wiley   +1 more source

HnRPD/AUF1 facilitates human ovarian cancer progression through activating FLI1 and maintaining cisplatin resistance. [PDF]

Mol Cancer
Tang C, Zhu C, An Z, Cao B, Xu Q, Li L, Bao Y, Li J.   +7 more
europepmc   +1 more source

CNTN5 Promotes Invasion and Metastasis in Non‐Small Cell Lung Cancer by Regulating YAP1 Nuclear Translocation

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Contactin‐5 (CNTN5) is upregulated in non‐small cell lung cancer (NSCLC) and associated with metastasis and poor prognosis. Mechanistically, CNTN5 interacts with PTPN13 to promote YAP1 nuclear translocation and transcriptional activation, enhancing NSCLC cell migration and invasion in vitro and metastasis in vivo.
Jiarui Wang, Mengtao Wang, Yanze Yin, Ao Zeng, Keyi Chen, Zhilong Xu, Jie Dai   +6 more
wiley   +1 more source

β-catenin mutation reprograms ketone body metabolism to drive hepatocellular carcinoma metastasis and resistance to ketogenic therapy via transcriptional activation of OXCT1. [PDF]

Cell Death Dis
Li H, Qian L, Ji Y, Geng Y, Lu Y, Zhang L, Xu Y, Zong W, Jiang X, Zhou X, Wen J, Liu D, Wang Y, Li Y, Li B, Ma H, Yu D.   +16 more
europepmc   +1 more source

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation

MedComm, Volume 7, Issue 9, September 2026.
This study reveals that Lcn2 regulates ferroptosis after ICH via the Keap1/Nrf2 axis. Neuronal Lcn2 deletion reduces lipid peroxidation, restores mitochondrial function, and improves ferroptosis. Keap1 Tyr572Ala mutant acts as a molecular switch whose effects invert with Lcn2 status.
Ya‐nan Dou, Hongkang Hu, Qinghua Li, Guangming Wang, Lijun Hou, Junbin Liu, Buyi Zheng, Ying Li, Guohan Hu, Zhou Fei, Xia Li, Li Wang, Jialiang Wei, Lei Jiang, Xiaowei Fei   +14 more
wiley   +1 more source

RUNX2 Represses the EWS-FLI1-mediated Transcription in Ewing's Sarcoma Cells. [PDF]

Cancer Genomics Proteomics
Kitagawa T, Baron B, Okita H, Hamada J, Nakagawa K, Kobayashi M, Ohta T, Kuramitsu Y.   +7 more
europepmc   +1 more source

METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent Ferroptosis

MedComm, Volume 7, Issue 9, September 2026.
METTL14‐mediated N6‐methyladenosine aggravates ischemia/reperfusion‐induced acute lung injury by enhancing YTHDF1‐dependent USP30 expression. USP30 stabilizes NCOA4 through deubiquitination, thereby promoting ferritinophagy, iron accumulation, lipid peroxidation, and ferroptosis in lung epithelial cells.
Aming Sang, Qiongyue Zhang, Xianwu Zhou, Xiaohua Wang, Jin Wang, Xuemin Song, Li Li, Ling Li, Xinyi Li   +8 more
wiley   +1 more source

ATG5 Plays a Role in <i>Toxoplasma gondii</i> Replication and Egress Within Host Cells. [PDF]

Transbound Emerg Dis
Wu F, Wu S, Ding Q, Shi Z, Liang Y, Chen H, Zhang X, Mi J, Chen M, Xu Q.   +9 more
europepmc   +1 more source