Results 161 to 170 of about 51,346 (240)

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Overexpression and knockdown of 5-lipoxygenase regulates the migration and invasion of colorectal cancer cells. [PDF]

Oncol Lett
Li X, Huge J, Wang X, Zhou J, Li X, Gao X, Shi T, Bai C.   +7 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Amino-acids-mTORC1-driven DDA1 phosphorylation promotes DNA repair and glioblastoma progression. [PDF]

Cell Commun Signal
Chen X, Wang Z, Yan A, Liu Y, Zhu R, Li L, Xu D, Liu R, Zhan X, Yin B, Han W, Peng X.   +11 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Small ruminant lentiviruses in dairy goats under tropical conditions: evidence of recombinant genotypes. [PDF]

Trop Anim Health Prod
da Cunha NC, de Oliveira Campello A, Machado LDS, Dias TS, Silva TR, de Almeida Figueira A, da Silva BPM, Gregory L, Colitti B, Lima da Costa Abreu D, Magalhães IFB, do Nascimento ER, Balaro MFA.   +12 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging. [PDF]

Protein Cell
Lu H, Cai L, Lv D, Sun G, Lei J, Ning T, Xin Z, Huang H, Jing Y, Huang D, Sun S, Ma S, Zhang W, Gao F, Chen R, Qin Y, Song W, Xiang AP, Izpisua Belmonte JC, Liu GH, Qu J, Wang S.   +21 more
europepmc   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells. [PDF]

PLoS Pathog
Gracias S, Le Seac'h E, Donaire-Carpio S, Vuillier F, Vendramini L, Moundib A, Temmam S, Rutkowska M, Donati F, Cupic A, Juste J, Martinez-Romero C, Morel N, Schwartz O, Krogan NJ, Miorin L, Müller MA, Demeret C, Munier S, Roingeard P, Batra J, Garcia-Sastre A, Caval V, Jouvenet N.   +23 more
europepmc   +1 more source