Results 141 to 150 of about 51,346 (240)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2. [PDF]

NPJ Vaccines
West GE, Morse RB, Sievers BL, Abdullahi A, Kamelian K, Cheng MTK, CITIID-NIHR BioResource COVID-19 Collaboration, Stewart DG, Diamond D, Altaf M, Ceron-Gutierrez L, Sokolova O, Robertson DL, Lytras S, Döffinger R, Wilson SJ, Rihn SJ, Gupta RK.   +17 more
europepmc   +1 more source

The Nef protein of primate lentiviruses

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may ...
Trono, Didier, Piguet, V
core   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells. [PDF]

Stem Cell Reports
Zhang K, Liang H, Chen S.
europepmc   +1 more source

Immunohistochemical Characterisation of Mismatch Repair Proteins in Feline Cancers: A Pilot Study Using Validated Cross‐Reactive Antibodies

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study, we established a practical immunohistochemistry (IHC) approach for evaluating feline MMR proteins by ...
Shoma Nishibori, Masashi Sakurai, Yumiko Kagawa, Kazuo Nishigaki, Takayuki Nakagawa, Sakuya Inanaga, Masaya Igase, Takuya Mizuno   +7 more
wiley   +1 more source

Histone lactylation boosted SET8 potentiates carcinogenesis and angiogenesis of pancreatic ductal adenocarcinoma by cooperating with MTA1/NuRD complex. [PDF]

J Transl Med
Liu X, Tuergong A, Wang M, Shi W, Tian X, Ting X, Cui L, Si W.   +7 more
europepmc   +1 more source

Mechanism of ORC1 Regulating Cancer Stemness and Cisplatin Resistance in Non‐Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Elevated ORC1 expression in non‐small cell lung cancer (NSCLC) simultaneously activates cancer stemness and epithelial‐mesenchymal transition (EMT). Upregulation of stemness‐associated factors (NANOG, LGR5, CD133+CD44+ CSCs) and EMT transcription factors (SNAI1, SNAI2, TWIST1) synergistically induce MDR1 overexpression. Increased MDR1 ultimately drives
Jianhui Sheng, Yingjian Song
wiley   +1 more source

Sirt1 transgene delivery improves diabetes-impaired wound healing. [PDF]

Bioact Mater
Luo R, Wang H, Duan C, Jen M, Kuo HY, Wang X, Mrksich M, Ameer G.   +7 more
europepmc   +1 more source

Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction

Aging Cell, Volume 25, Issue 10, October 2026.
Hepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Kangkang Yang, Yuli Jian, Fusheng Pang, Ming Ying, Qian Yang, Nian Liu, Shujing Wang, Yingjie Wu   +7 more
wiley   +1 more source