Results 41 to 50 of about 62,168 (302)

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells [PDF]

, 2013
Using a screening strategy, we identified the tetratricopeptide repeat (TPR) motif protein, Tetratricopeptide repeat domain 5 (TTC5, also known as stress responsive activator of p300 or Strap) as required for the survival of human acute myeloid leukemia (
Huang, X., Lynch, J.T., Somervaille, T.C.P., Somerville, T,D,D,, Spencer, G,J,   +4 more
core   +1 more source

Self-replicating recombinant virus-like particles of lentivirus proliferating in glioblastoma cells and normal human macrophages

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Both attenuated and inactivated vaccines are used in disease control. Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. Immunity
Herman D. Moshkoff, Andrey E. Moshkoff, Dmitry A. Moshkoff   +2 more
doaj   +1 more source

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses

Veterinary Sciences, 2015
The emergence of human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS) in infected humans has resulted in a global pandemic that has killed millions. HIV-1 and HIV-2 belong to the lentivirus genus of the Retroviridae family.
Deepanwita Bose, Jean Gagnon, Yahia Chebloune   +2 more
doaj   +1 more source

Common mechanism of infection by lentiviruses [PDF]

Nature, 1997
No abstract available.
Willett, B.J., Hosie, M.J., Neil, J.C., Turner, J.D., Hoxie, J.A.   +4 more
openaire   +3 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Comparison of immunoassay and real-time PCR methods for the detection of Jembrana disease virus infection in Bali cattle [PDF]

, 2009
A sensitive diagnostic assay for the detection of infections with the bovine lentivirus Jembrana disease virus (JDV) is required in Indonesia to control the spread of Jembrana disease. Immunoassays are used routinely but are compromised by cross-reactive
Desport, M., Hartaningsih, N., Lewis, J.R., McNab, T., Tenaya, I.W., Wilcox, G.E.   +5 more
core   +2 more sources

Microbial agents in macroscopically healthy mammary gland tissues of small ruminants [PDF]

PeerJ, 2017
Background Health of mammary glands is fundamental for milk and dairy products hygiene and quality, with huge impacts on consumers welfare. Methods This study aims to investigate the microbial agents (bacteria, fungi and lentiviruses) isolated from 89 ...
Liliana Spuria, Elena Biasibetti, Donal Bisanzio, Ilaria Biasato, Daniele De Meneghi, Patrizia Nebbia, Patrizia Robino, Paolo Bianco, Michele Lamberti, Claudio Caruso, Alessia Di Blasio, Simone Peletto, Loretta Masoero, Alessandro Dondo, Maria Teresa Capucchio   +14 more
doaj   +2 more sources

Ancient lentiviruses leave their mark [PDF]

Proceedings of the National Academy of Sciences, 2007
One of the most remarkable insights from the human genome project was that more genetic material is devoted to vertically transmitted and defective remnants of once-infectious retroviruses, commonly referred to as endogenous retroviruses (ERVs), than to human protein-coding DNA (1). Current estimates place the ERV component of the human genome at 5–8%,
openaire   +2 more sources

The comparative value of feline virology research: can findings from the feline lentiviral vaccine be translated to humans? [PDF]

, 2017
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV).
Beczkowski, Paweł M., Harris, Matthes, Hosie, Margaret J., Logan, Nicola, Techakriengkrai, Navapon, Willett, Brian   +5 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source