Results 51 to 60 of about 51,346 (240)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction

Viruses
The evolutionary arms race between host restriction factors and viral antagonists provides crucial insights into immune system evolution and viral adaptation.
David Nicolas Giuseppe Huebert, Atefeh Ghorbani, Shaw Yick Brian Lam, Mani Larijani   +3 more
doaj   +1 more source

Macaques as model hosts for studies of HIV-1 infection

Frontiers in Microbiology, 2013
Increasing evidence indicates that the host range of primate lentiviruses is in part determined by their ability to counteract innate restriction factors that are effectors of the type 1 interferon (IFN-1) response.
Anisha eMisra, Rajesh eThippeshappa, Jason T Kimata   +2 more
doaj   +1 more source

Interspecific transmission of small ruminant lentiviruses from goats to sheep. [PDF]

, 2019
Abstrract: This study was conducted in order to evaluate the transmission of caprine lentivirus to sheep using different experimental groups. The first one (colostrum group) was formed by nine lambs receiving colostrum from goats positive for small ...
ARAÚJO, J. F., SOUSA, A. L. M. de, COSTA, J. N., LIMA, C. C. V. de, SOUZA, T. S. de, PINHEIRO, D. N. S., ANDRIOLI, A., FERNANDES, F. M. C., COSTA NETO, A. O., PINHEIRO, R. R., AZEVEDO, D. A. A. de   +10 more
core   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Lentiviral mediated transgenesis by in vivo manipulation of spermatogonial stem cells. [PDF]

PLoS ONE, 2011
This report describes a technique for the generation of transgenic mice by in vivo manipulation of spermatogonial stem cells with a high rate of success.
Lalit Sehgal, Rahul Thorat, Nileema Khapare, Amitabha Mukhopadhaya, Mugdha Sawant, Sorab N Dalal   +5 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Study of possible intrauterine infection of goat fetus with caprine arthritis-encephalitis virus

Ветеринария сегодня
Caprine arthritis-encephalitis is a serious challenge for the modern goat breeding both in Russia and abroad. The disease is quite widespread in our country, causing serious economic damage to the backyard and family-operated farm owners.
V. Yu. Koptev, N. A. Shkil, N. Yu. Balybina, T. N. Belenkova   +3 more
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Cellular Restriction Factors of Feline Immunodeficiency Virus

Viruses, 2011
Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors ...
Carsten Münk, Jörg Zielonka
doaj   +1 more source