Results 21 to 30 of about 51,346 (240)

A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses [PDF]

, 2016
Mammals have co-evolved with lentiviruses for a long time. As evidence, viral infectivity factor (Vif), encoded by lentiviruses, antagonizes the anti-viral action of cellular APOBEC3 of their hosts. Here, we address the co-evolutionary dynamics of bovine
Kobayashi, Tomoko, Yamada, Eri, Ren, Fengrong, Izumi, Taisuke, Misawa, Naoko, Koyanagi, Yoshio, Sato, Kei, Yoshikawa, Rokusuke, Nakano, Yusuke, Miyazawa, Takayuki   +9 more
core   +1 more source

Soroprevalência da infecção por lentivírus de pequenos ruminantes em abatedouros do estado de Pernambuco, Brasil

Arquivos do Instituto Biológico, 2016
RESUMO: A soroprevalência da infecção por lentivírus de pequenos ruminantes (LVPR) foi determinada em amostras de soros sanguíneos de caprinos e ovinos de aptidão cárnea provenientes de abatedouros de dez municípios do estado de Pernambuco, Brasil.
Elialdo Xavier Melo, Erivânia Camelo de Almeida, Kátia Maria Nascimento Mendonça, Sérgio Alves do Nascimento, Jean Carlos Ramos Silva, Maria Fernanda Vianna Marvulo, Huber Rizzo, Roberto Soares de Castro   +7 more
doaj   +1 more source

Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface [PDF]

, 2010
Lentiviruses are widespread in a variety of vertebrates, often associated with chronic disease states. However, until the recent discovery of the prehistoric endogenous lentiviruses in rabbits (RELIK) and lemurs (PSIV), it was thought that lentiviruses ...
Lesley F. Haire, Stoye, Jonathan P, Jonathan P. Stoye, Taylor, WR, Melvyn W. Yap, Taylor, William R., Laura E. Robertson, Robertson, Laura E, Taylor, William R, Goldstone, David C., David C. Goldstone, William R. Taylor, Taylor, IA, Haire, Lesley F., Yap, Melvyn W., Robertson, Laura E., Yap, Melvyn W, Robertson, LE, Stoye, Jonathan P., Goldstone, DC, Aris Katzourakis, Katzourakis, A, Yap, MW, Taylor, Ian A., Haire, Lesley F, Goldstone, David, Ian A. Taylor, Taylor, Ian A, Haire, LF, Katzourakis, Aris, Stoye, JP   +30 more
core   +1 more source

Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses. [PDF]

PLoS Pathogens, 2013
Naturally circulating lentiviruses are abundant in African primate species today, yet their origins and history of transmitting between hosts remain obscure. As a means to better understand the age of primate lentiviruses, we analyzed primate genomes for
Alex A Compton, Michael Emerman
doaj   +1 more source

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses

Viruses, 2021
The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to ...
Alžběta Dostálková, Barbora Vokatá, Filip Kaufman, Pavel Ulbrich, Tomáš Ruml, Michaela Rumlová   +5 more
doaj   +1 more source

Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology

STAR Protocols, 2021
Summary: We present a detailed protocol for gene editing in adipocytes using the CRISPR-Cas technology. This protocol describes sgRNA design, preparation of lentiCRISPR-sgRNA vectors, functional validation of sgRNAs, preparation of lentiviruses, and ...
Yan Qiu, Qiurong Ding
doaj   +1 more source

Growth of Lion and Puma Lentiviruses in Domestic Cat Cells and Comparisons with FIV [PDF]

, 1997
Feline immunodeficiency virus (FIV-Fca) is a lentivirus that causes gradual immunological deterioration in domestic cats. Lentiviruses related to FIV have been detected in several nondomestic feline species; the biologic significance of these viruses ...
Hardy, William D., Edward A. Hoover, Jill P. Slattery, O'brien, Stephen J., VandeWoude, Sue, Slattery, Jill P., Stephen J. O'brien, O\u27Brien, Stephen J., Zuckerman, Evelyn E., Ken Langelier, Hoover, Edward A., Evelyn E. Zuckerman, William D. Hardy, Langelier, Ken, Sue Vandewoude   +14 more
core   +2 more sources

In silico segmentations of lentivirus envelope sequences

BMC Bioinformatics, 2007
Background The gene encoding the envelope of lentiviruses exhibits a considerable plasticity, particularly the region which encodes the surface (SU) glycoprotein.
Leroux Caroline, Piau Didier, Boissin-Quillon Aurélia   +2 more
doaj   +1 more source

Gene Therapy Applications of Non-Human Lentiviral Vectors

Viruses, 2020
Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients. LVs hold notable and inherent advantages over other
Altar M. Munis
doaj   +1 more source

An endogenous lentivirus in the germline of a rodent

Retrovirology, 2022
Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline.
Roziah Kambol, Anna Gatseva, Robert J. Gifford   +2 more
doaj   +1 more source