Results 21 to 30 of about 46,404 (214)
Gene Therapy Applications of Non-Human Lentiviral Vectors
Viruses, 2020 Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients. LVs hold notable and inherent advantages over other
Altar M. Munis
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An endogenous lentivirus in the germline of a rodent
Retrovirology, 2022 Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline.
Roziah Kambol +2 more
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Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology
STAR Protocols, 2021 Summary: We present a detailed protocol for gene editing in adipocytes using the CRISPR-Cas technology. This protocol describes sgRNA design, preparation of lentiCRISPR-sgRNA vectors, functional validation of sgRNAs, preparation of lentiviruses, and ...
Yan Qiu, Qiurong Ding
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Stem Cell Reports, 2017 Recent studies using defined transcription factors to convert skin fibroblasts into chondrocytes have raised the question of whether osteo-chondroprogenitors expressing SOX9 and RUNX2 could also be generated during the course of the reprogramming process.
Yinxiang Wang +7 more
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Non-Primate Lentiviral Vectors and Their Applications in Gene Therapy for Ocular Disorders
Viruses, 2018 Lentiviruses have a number of molecular features in common, starting with the ability to integrate their genetic material into the genome of non-dividing infected cells.
Vincenzo Cavalieri +2 more
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Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Both attenuated and inactivated vaccines are used in disease control. Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. Immunity
Herman D. Moshkoff +2 more
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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
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Microbial agents in macroscopically healthy mammary gland tissues of small ruminants [PDF]
PeerJ, 2017 Background Health of mammary glands is fundamental for milk and dairy products hygiene and quality, with huge impacts on consumers welfare. Methods This study aims to investigate the microbial agents (bacteria, fungi and lentiviruses) isolated from 89 ...
Liliana Spuria +14 more
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Small ruminant lentiviruses: economic and productive losses, consequences of the disease
Arquivos do Instituto Biológico, 2018 : Small ruminant lentiviruses, caprine arthritis encephalitis virus, and Maedi-Visna virus cause diseases that result in significant productive losses, mostly in dairy animals.
Dalva Alana Aragão de Azevedo +6 more
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MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
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