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Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses
Veterinary Sciences, 2015 The emergence of human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS) in infected humans has resulted in a global pandemic that has killed millions. HIV-1 and HIV-2 belong to the lentivirus genus of the Retroviridae family.
Yahia Chebloune +2 more
exaly +4 more sources
Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins
Viruses, 2020 Viral protein R (Vpr) is an accessory protein found in various primate lentiviruses, including human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) as well as simian immunodeficiency viruses (SIVs).
Yoko Aida +2 more
exaly +4 more sources
Virus-receptor mediated transduction of dendritic cells by lentiviruses enveloped with glycoproteins derived from Semliki Forest virus. [PDF]
PLoS ONE, 2011 Lentiviruses have recently attracted considerable interest for their potential as a genetic modification tool for dendritic cells (DCs). In this study, we explore the ability of lentiviruses enveloped with alphaviral envelope glycoproteins derived from ...
Steven Froelich +4 more
doaj +2 more sources
Microbiology Spectrum, 2023 FAM46C is a multiple myeloma (MM) tumor suppressor whose function is only starting to be elucidated. We recently showed that in MM cells FAM46C triggers apoptosis by inhibiting autophagy and altering intracellular trafficking and protein secretion.
Marilena Mancino +12 more
doaj +1 more source
Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells
mBio, 2023 HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (exportin-1 ...
Ryan T. Behrens +10 more
doaj +1 more source
Microbiology Spectrum, 2022 HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson +5 more
doaj +1 more source
Pathogens, 2023 Small ruminant lentiviruses (SRLVs) are transmitted among ovine and caprine species. This disease is a severe problem for small ruminant production, not only for animals’ well-being but also for flocks’ efficiency.
João Jacob-Ferreira +4 more
doaj +1 more source
mBio, 2020 Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral ...
Wen Li +13 more
doaj +1 more source
Transmission of caprine arthritis encephalitis virus between sheep
Ciência Rural, 2018 : This study was conducted to evaluate caprine arthritis encephalitis virus (CAEV) transmission among sheep using 15 lambs that were distributed in 2 experimental groups.
Carla Caroline Valença de Lima +7 more
doaj +1 more source
The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present
Viruses, 2021 The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Keiya Uriu +3 more
doaj +1 more source