Small ruminant lentiviruses: economic and productive losses, consequences of the disease [PDF]
Arquivos do Instituto Biológico, 2018 : Small ruminant lentiviruses, caprine arthritis encephalitis virus, and Maedi-Visna virus cause diseases that result in significant productive losses, mostly in dairy animals.
Dalva Alana Aragão de Azevedo +6 more
doaj +4 more sources
Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]
Scientific Reports, 2017 G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
Rosalba Perrone +3 more
doaj +2 more sources
Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses [PDF]
Viruses, 2018 Lentiviruses are infectious agents of a number of animal species, including sheep, goats, horses, monkeys, cows, and cats, in addition to humans. As in the human case, the host immune response fails to control the establishment of chronic persistent ...
Lorena de Pablo-Maiso +7 more
doaj +3 more sources
Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface. [PDF]
PLoS Pathogens, 2015 The widespread distribution of lentiviruses among African primates, and the lack of severe pathogenesis in many of these natural reservoirs, are taken as evidence for long-term co-evolution between the simian immunodeficiency viruses (SIVs) and their ...
Kevin R McCarthy +3 more
doaj +2 more sources
PLoS Pathogens, 2017 Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and ...
Dominik Hotter +10 more
doaj +2 more sources
Immunization against Small Ruminant Lentiviruses [PDF]
Viruses, 2013 Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare.
Beatriz Amorena +2 more
doaj +2 more sources
Anti-tetherin activities in Vpu-expressing primate lentiviruses [PDF]
Retrovirology, 2010 Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells.
Haworth Kevin G +5 more
doaj +2 more sources
The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys. [PDF]
PLoS Pathogens, 2015 Cross-species transmissions of viruses from animals to humans are at the origin of major human pathogenic viruses. While the role of ecological and epidemiological factors in the emergence of new pathogens is well documented, the importance of host ...
Lucie Etienne +5 more
doaj +2 more sources
Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 [PDF]
, 2013 SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr
Emerman, M +23 more
core +2 more sources
The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]
, 1999 Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J. +3 more
core +1 more source