Results 51 to 60 of about 62,168 (302)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]

, 2015
Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric, Biffoni, Mauro, Chung, Hye Kyung, Farrell, Nicholas, Labranche, Celia, Lewis, Mark G., Montefiori, David, Nickel, Gabrielle, Pal, Ranajit, PALAMARA, ANNA TERESA, Robert Guroff, Marjorie, Sacha, Jonah B., Savarino, Andrea, Shytaj, Iart Luca, Vargas Inchaustegui, Diego   +14 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Seroprevalence of Zika virus in wild African green monkeys and baboons [PDF]

, 2017
Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined,
Adam L. Bailey, Andrea M. Weiler, Anna J. Jasinska, Clifford J. Jolly, Connor R. Buechler, Cristian Apetrei, David H. O’Connor, Gabrielle L. Barry, Jane E. Phillips-Conroy, Jeffrey Rogers, John Schoggins, Laurel M. Stewart, Meghan E. Breitbach, Nelson B. Freimer, Thomas C. Friedrich   +14 more
core   +3 more sources

Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes

Journal of Virology
Small ruminant lentiviruses (SRLVs) are a heterogeneous group of viruses that infect goats and sheep worldwide, for which no cures or effective vaccines are available.
Barbara Colitti, Daniele Avanzato, Riccardo Moretti, Irati Moncayola, Margherita Profiti, Stefania Chessa, Paola Sacchi, Sergio Rosati, Ramses Reina   +8 more
doaj   +1 more source

Optimized Transgene Delivery Using Third‐Generation Lentiviruses [PDF]

Current Protocols in Molecular Biology, 2020
AbstractThe lentivirus system enables efficient genetic modification of both dividing and non‐dividing cells and therefore is a useful tool for elucidating developmental processes and disease pathogenesis. The development of third‐generation lentiviruses has resulted in improved biosafety, low immunogenicity, and substantial packaging capabilities ...
Gill, Katherine P., Denham, Mark
openaire   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Identification of a WNT5A-Responsive Degradation Domain in the Kinesin Superfamily Protein KIF26B. [PDF]

, 2018
Noncanonical WNT pathways function independently of the β-catenin transcriptional co-activator to regulate diverse morphogenetic and pathogenic processes.
Choi, Shannon S, Cohen, Michael, Fierro, Fernando A, Ho, Hsin-Yi Henry, Hum, Jennie, Karuna, Edith P, Scales, Michael K   +6 more
core   +2 more sources

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Preferential lentiviral targeting of astrocytes in the central nervous system. [PDF]

PLoS ONE, 2013
The ability to visualize and genetically manipulate specific cell populations of the central nervous system (CNS) is fundamental to a better understanding of brain functions at the cellular and molecular levels.
Michael Fassler, Itai Weissberg, Nitzan Levy, Felipe Diaz-Griffero, Alon Monsonego, Alon Friedman, Ran Taube   +6 more
doaj   +1 more source