Results 101 to 110 of about 2,380,940 (353)
BMC Cancer, 2008 Background Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin receptor have recently been implicated
Anyanwu Stanley N +9 more
doaj +1 more source
Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling
Nature Neuroscience, 2012 Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial ...
Hu Huang +13 more
semanticscholar +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Compulsive exercise is a common feature of eating disorders (EDs) but understanding of factors that drive this symptom remains limited. This pilot trial evaluated psychobiological response to in‐laboratory exercise among females (14–22 years) with and without restrictive eating pathology.
Katherine Schaumberg +5 more
wiley +1 more source
Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain
The Journal of comparative neurology, 2012 The hormones leptin and ghrelin act in apposition to one another in the regulation of body weight homeostasis. Interestingly, both leptin receptor expression and ghrelin receptor expression have been observed within many of the same nuclei of the central
M. Perelló +8 more
semanticscholar +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Pregnancy in a woman with a leptin-receptor mutation.
New England Journal of Medicine, 2012 This case report describes a spontaneously conceived pregnancy in a woman with a leptin receptor mutation, an observation that calls into question the belief that leptin is necessary for normal reproductive function.
J. Nizard, M. Dommergues, K. Clément
semanticscholar +1 more source
Role of Leptin in Cardiovascular Diseases
Frontiers in Endocrinology, 2020 The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the regulation of energy balance and cell metabolism, for controlling inflammatory and immune responses, and for the maintenance of homeostasis of the ...
M. Poetsch, A. Strano, K. Guan
semanticscholar +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum
Pathogens, 2020 Neospora caninum is an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic ...
Luzia Teixeira +5 more
doaj +1 more source
PLoS ONE, 2012 Background The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain ...
Michael Schaab +9 more
semanticscholar +1 more source