Results 81 to 90 of about 73,797 (197)

Hypothalamic Leptin Receptor-Expressing Neurons: A Regulator of Anxiety-Feeding Imbalance in Animal Models of Anorexia Nervosa. [PDF]

MedComm (2020)
Liang J, Zheng Y, Chen Z.
europepmc   +1 more source

Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries

Clinical &Experimental Allergy, EarlyView.
There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna, Saibal Moitra, Anna Freeman, Ben Ainsworth, Rebecca Knibb, Ramesh Kurukulaaratchy, Adel H. Mansur   +6 more
wiley   +1 more source

GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis. [PDF]

Nat Commun
Suhardi VJ, Oktarina A, Niu Y, Thomson AL, Alphonsus J, Suhardi N, McCormick J, Ayturk U, Greenblatt MB, Ivashkiv LB, Bostrom MPG, Yang X.   +11 more
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide. [PDF]

Acta Neuropsychiatr
Aytac HM, Oyaci Y, Aytac E, Pehlivan M, Burhan HS, Alptekin FB, Pehlivan S.   +6 more
europepmc   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions. [PDF]

Front Endocrinol (Lausanne)
Prodan A, Dzyubanovsky I, Halabitska I, Petakh P, Kamyshna I, Kamyshnyi O.   +5 more
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Protein Restriction Increases Soluble Leptin Receptor via a Leptin-Dependent Mechanism Without Affecting Leptin-Induced Appetite Suppression in Mice. [PDF]

Nutrients
Uchiyama M, Toyama T, Takei Y, Ishii H, Takenaka A.   +4 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source