Molecules, 2017 The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of ...
Paweł Olczyk +9 more
doaj +1 more source
Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes
PLoS ONE, 2013 The leptin (LEP) and its receptor (LEPR) regulate food intake and energy balance through hypothalamic signaling. However, the LEP-LEPR axis seems to be more complex and its expression regulation has not been well described. In pigs, LEP and LEPR genes have been widely studied due to their relevance. Previous studies reported significant effects of SNPs
Pérez-Montarelo, Dafne +8 more
openaire +5 more sources
Influence of leptin on arterial distensibility - A novel link between obesity and cardiovascular disease? [PDF]
, 2002 Background-The mechanisms by which obesity increases the risk of atherosclerotic cardiovascular disease (CVD) are poorly understood. In experimental models, leptin, a hormone produced by adipose tissue, has been shown adversely to affect vascular health.
Kattenhorn, M +7 more
core
Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]
, 2009 Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C. +15 more
core +1 more source
Hypoxic Living and Exercise Training Alter Adipose Tissue Leptin/Leptin Receptor in Rats
Frontiers in Physiology, 2016 Background: Hypobaric hypoxia results in weight loss in obese individuals, and exercise training is advocated for the treatment of obesity and its related metabolic dysfunctions.
Yingli Lu +6 more
doaj +1 more source
Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. [PDF]
, 2014 BACKGROUND Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional ...
Stewart Gilmour +15 more
core +2 more sources
Tumor Biology, 2017 Leptin, one of the main hormones controlling energy homeostasis, has been associated with different cancer types. In oral cancer, its effect is not well understood.
Eliane Macedo Sobrinho Santos +11 more
doaj +1 more source
Cancer Medicine, 2020 Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide. Despite the growing evidence associating obesity and adipokines, particularly leptin and its receptors, with cancer development and progression, it is still a ...
Hala Fawzy Mohamed Kamel +2 more
doaj +1 more source
Peripheral Sympathetic Leptin Receptor Signaling Regulates Sympathetic Innervation of White Adipose Tissue and Diet-Induced Thermogenesis [PDF]
The rising prevalence of obesity poses a significant public health challenge, with profound implications for metabolic disorders and associated health risks. In the United States, approximately 40% of adults are considered obese.
Silva, Felipe C
core +1 more source
Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A [PDF]
, 2010 Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies.
Illig, T +154 more
core +2 more sources