Results 71 to 80 of about 75,788 (264)

Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir

Molecules, 2017
The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of ...
Paweł Olczyk, Robert Koprowski, Katarzyna Komosinska-Vassev, Agnieszka Jura-Półtorak, Katarzyna Winsz-Szczotka, Kornelia Kuźnik-Trocha, Łukasz Mencner, Alicja Telega, Diana Ivanova, Krystyna Olczyk   +9 more
doaj   +1 more source

Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes

PLoS ONE, 2013
The leptin (LEP) and its receptor (LEPR) regulate food intake and energy balance through hypothalamic signaling. However, the LEP-LEPR axis seems to be more complex and its expression regulation has not been well described. In pigs, LEP and LEPR genes have been widely studied due to their relevance. Previous studies reported significant effects of SNPs
Pérez-Montarelo, Dafne, Fernández, Almudena, Barragán, Carmen, Noguera, José L., Folch, Josep María, Rodríguez, M. Carmen, Óvilo Martín, Cristina, Silió, Luis, Fernández, Ana Isabel   +8 more
openaire   +5 more sources

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Hypoxic Living and Exercise Training Alter Adipose Tissue Leptin/Leptin Receptor in Rats

Frontiers in Physiology, 2016
Background: Hypobaric hypoxia results in weight loss in obese individuals, and exercise training is advocated for the treatment of obesity and its related metabolic dysfunctions.
Yingli Lu, Lianshi Feng, Minhao Xie, Li Zhang, Jianfang Xu, Zihong He, Tongjian You   +6 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma

Tumor Biology, 2017
Leptin, one of the main hormones controlling energy homeostasis, has been associated with different cancer types. In oral cancer, its effect is not well understood.
Eliane Macedo Sobrinho Santos, Talita Antunes Guimarães, Hércules Otacílio Santos, Lilian Mendes Borborema Cangussu, Sabrina Ferreira de Jesus, Carlos Alberto de Carvalho Fraga, Claudio Marcelo Cardoso, Sérgio Henrique Souza Santos, Alfredo Maurício Batista de Paula, Ricardo Santiago Gomez, André Luiz Sena Guimarães, Lucyana Conceição Farias   +11 more
doaj   +1 more source

Assessment of expression levels of leptin and leptin receptor as potential biomarkers for risk of prostate cancer development and aggressiveness

Cancer Medicine, 2020
Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide. Despite the growing evidence associating obesity and adipokines, particularly leptin and its receptors, with cancer development and progression, it is still a ...
Hala Fawzy Mohamed Kamel, Anmar M. Nassir, Abeer A. Al refai   +2 more
doaj   +1 more source

Resumption of Menses and Normalisation of Body Weight in Adolescents Undergoing Specialised Treatment for Anorexia Nervosa Inpatient or Outpatient Treatment

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To predict resumption of menses (ROM) in patients with anorexia nervosa (AN). Method Females aged 9–17 years with AN, receiving inpatient multimodal treatment (IMT) or family‐based treatment (FBT) underwent assessments at baseline, 6‐month and 12‐month follow‐up (12FU).
Annika Woltmann, Linus Imken, Vivien Kaiser, Johanna L. Keeler, Daniel Le Grange, Christoph U. Correll, Verena Haas   +6 more
wiley   +1 more source

Prevalence of insulin dysregulation in a sport horse population as determined by traditional and stall‐side testing

Equine Veterinary Journal, EarlyView.
Abstract Background The prevalence of insulin dysregulation (ID) has not been investigated in sport horses. Stall‐side insulin assays offer convenience but need further validation. Objectives To determine the prevalence of and risk factors for ID in a sport horse population using an oral sugar test (OST) and assess agreement between stall‐side and ...
Kimberly L. Hallowell, Caitlyn R. Horne, Cary S. Miller, Sara R. Tufts, Katarzyna Dembek, Kim R. Love, Andrew W. van Eps, Lauren V. Schnabel   +7 more
wiley   +1 more source

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.

PLoS Biology, 2011
Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known.
Qiang Liu, Juan Zhang, Celina Zerbinatti, Yan Zhan, Benedict J Kolber, Joachim Herz, Louis J Muglia, Guojun Bu   +7 more
doaj   +1 more source