Results 51 to 60 of about 1,272,125 (151)

Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway

Computational and Structural Biotechnology Journal, 2022
Leptin is the pivotal modulator in the onset and progression of breast cancer and obesity. Celastrol, which is extracted from the roots of Tripterygium wilfordi plants, exerts various anticancer bioactivities and has recently emerged as a candidate to ...
Pingping Chen, Bin Wang, Meng Li, Chunxue Cui, Fei Liu, Yonggang Gao   +5 more
doaj   +1 more source

Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients

Mediators of Inflammation, 2010
The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia ...
Alexander Koch, Ralf Weiskirchen, Henning W. Zimmermann, Edouard Sanson, Christian Trautwein, Frank Tacke   +5 more
doaj   +1 more source

Leptin receptor signaling: pathways to leptin resistance

Frontiers in Bioscience, 2011
The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
openaire   +2 more sources

Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer [PDF]

, 2017
Aim of the study: Breast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women.
Waleed Elnahas Rashad, Mohmed Ali Atwa, Nora Marzouk Elkady, Mona Abo-Bakr El-Hussiny, Dalia A. Shaheen   +4 more
core   +1 more source

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core   +1 more source

Adaptive Evolution of Leptin in Heterothermic Bats [PDF]

, 2011
PMCID: PMC3217946This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Stephen J Rossiter, Shuyi Zhang, Yuan Lihong, Zuo, X, Zuo Xueguo, Gareth Jones, He, Guimei, Lin Benfu, Rossiter Stephen J., Rossiter, SJ, Zhang, Shuyi, Lin, B, Zhao, X, Zhao Xudong, Geiser Fritz, Geiser, F, Lihong Yuan, Yuan, Lihong, Fritz Geiser, He Guimei, He Lingjiang, Rossiter, Stephen J, Geiser, Fritz, He, Lingjiang, Zhang, S, Lingjiang He, Zuo, Xueguo, Lin, Benfu, Stephen J. Rossiter, Xudong Zhao, He, G, Zhao, Xudong, Yuan, L, Guimei He, Zhang Shuyi, Benfu Lin, Xueguo Zuo, He, L, Jones Gareth, Jones, Gareth, Jones, G   +40 more
core   +2 more sources

Leptin as a Key between Obesity and Cardiovascular Disease

Journal of Obesity & Metabolic Syndrome, 2020
Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly and ...
Ki-Woon Kang, Minho Ok, Seong-Kyu Lee
doaj   +1 more source

Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis [PDF]

, 2007
Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic
Al-Rubeaan, Khalid, Mohammad Al-Katari, Khalid Al-Rubeaan, Mohieldin, Mehad, Jones, Alan F., Kumar Sudhesh, Jones Alan F, Kumar, Sudhesh, Mehad Mohieldin, Al-Katari Mohammad, Al-Rubeaan Khalid, Mohieldin Mehad, Nasser M Al-Daghri, Sudhesh Kumar, Omar S Al-Attas, Al-Attas, Omar S., Alan F Jones, Al-Daghri, Nasser M., Al-Katari, Mohammad, Al-Attas Omar S, Al-Daghri Nasser M   +20 more
core   +1 more source

Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring

, 2010
In a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet
Garratt, Emma
core   +1 more source

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +3 more sources