Results 131 to 140 of about 75,788 (264)

GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis. [PDF]

Nat Commun
Suhardi VJ, Oktarina A, Niu Y, Thomson AL, Alphonsus J, Suhardi N, McCormick J, Ayturk U, Greenblatt MB, Ivashkiv LB, Bostrom MPG, Yang X.   +11 more
europepmc   +1 more source

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide. [PDF]

Acta Neuropsychiatr
Aytac HM, Oyaci Y, Aytac E, Pehlivan M, Burhan HS, Alptekin FB, Pehlivan S.   +6 more
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Protein Restriction Increases Soluble Leptin Receptor via a Leptin-Dependent Mechanism Without Affecting Leptin-Induced Appetite Suppression in Mice. [PDF]

Nutrients
Uchiyama M, Toyama T, Takei Y, Ishii H, Takenaka A.   +4 more
europepmc   +1 more source

Amylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early‐Phase Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The management of the disease of obesity has been transformed by incretin‐based therapies; however, additional and alternative therapeutic strategies are needed to address its biological complexity. This narrative review examines the physiology of amylin and the emerging role of amylin‐based therapies in obesity management.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions. [PDF]

Front Endocrinol (Lausanne)
Prodan A, Dzyubanovsky I, Halabitska I, Petakh P, Kamyshna I, Kamyshnyi O.   +5 more
europepmc   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons. [PDF]

Commun Biol
Kaiser L, Lee N, Zaunbrecher K, Kinney C, Williams J, Smith M, Noland RC, Yu S, Morrison CD, Berthoud HR, Münzberg H.   +10 more
europepmc   +1 more source

Amylin: A Multi‐Functional Pancreatic Hormone—A Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Amylin is a pancreatic beta‐cell hormone that sits at a systems hub connecting key aspects of energy metabolism. Amylin physiologically controls satiation, slows gastric emptying and limits postprandial glucagon release, while its actions also link homeostatic eating controls with reward driven behaviours via defined central nervous system ...
Christelle Le Foll, Thomas A. Lutz
wiley   +1 more source

Clinical Improvements with Setmelanotide in a 2-Year-Old Patient with Hyperphagia and Obesity due to Leptin Receptor Deficiency: A Case Report. [PDF]

Obes Facts
Pons MR, Gutierrez Vilar M, Rodriguez AP, Alonso JM.   +3 more
europepmc   +1 more source