Results 131 to 140 of about 73,797 (197)

KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus. [PDF]

FASEB J
Forzisi-Kathera-Ibarra E, Jo C, Castillo L, Gaur A, Lad P, Bortolami A, Roser C, Venkateswaran S, Dutto S, Selby M, Sampath H, Pan PY, Sesti F.   +12 more
europepmc   +1 more source

Setmelanotide in Bardet‐Biedl Syndrome: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith, Eric Sanfilippo, Lara Wine Lee   +2 more
wiley   +1 more source

Targeting the leptin receptor promotes MDA-MB-231 cells' metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue. [PDF]

Front Oncol
Encarnação CC, Amorim CS, Franco VA, Botelho LGX, Dos Santos RCM, Ramos-Andrade I, Kraemer-Aguiar LG, Barja-Fidalgo C, Moraes JA, Renovato-Martins M.   +9 more
europepmc   +1 more source

Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types. [PDF]

Int J Mol Sci
Klimont A, Ruciński M, Sawicka-Gutaj N, Szyszka M, Blatkiewicz M, Wierzbicki T, Karczewski M, Janicka-Jedyńska M, Ruchała M, Komarowska H.   +9 more
europepmc   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Editorial Expression of Concern: Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins. [PDF]

Exp Mol Med
europepmc   +1 more source

Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss. [PDF]

Metabolism
Francois M, Kaiser L, He Y, Xu Y, Salbaum JM, Yu S, Morrison CD, Berthoud HR, Münzberg H.   +8 more
europepmc   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Preliminary insight into the potential role of Leptin Receptor Polymorphisms in Type 2 Diabetes Risk: case-control study and bioinformatics analysis. [PDF]

J Diabetes Metab Disord
Sabeti Akbar-Abad M, Majidpour M, Keykha F, Maleki M, Piroozan Y, Saravani R, Zandhaghighi M, Shahriari H, Sargazi S.   +8 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source