Results 141 to 150 of about 75,788 (264)

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Leptin receptor gene influences pig gut microbiota both through feed intake and independently. [PDF]

Anim Microbiome
Suárez-Mesa R, Laghouaouta H, Estellé J, Seradj AR, Ros-Freixedes R, Pena RN, Estany J.   +6 more
europepmc   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population. [PDF]

Front Endocrinol (Lausanne)
Parmar N, Rathwa N, Patel R, Pramanik Palit S, Patel N, Shetty S, Dwivedi M, Begum R, Ramachandran AV.   +8 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Effect of Metabolic and Bariatric Surgery Associated with Changes in Weight Loss, Free Leptin Index, and Soluble Leptin Receptor. [PDF]

Metabolites
Basurto L, Basurto-Acevedo N, Oviedo N, Santa Cruz-Galicia E, Rodríguez-Martínez AI, Tesoro-Cruz E, Martínez-Murillo C, García-Estrada AG, Nájera Meneses AC, Manuel-Apolinar L.   +9 more
europepmc   +1 more source

Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective

Immunology, EarlyView.
Peripheral blood mononuclear cells (PBMCs) from individuals with metabolic syndrome (MetS) who were not using glucose‐and/or lipid lowering medication (GLLM) exhibited a broader cytokine production profile after in vitro antigen‐specific stimulation than PBMCs from individuals with MetS using such medications and from healthy donors.
Isabela Ghetti Macedo Isaac, Carolina do Prado Servian, Fernanda de Oliveira Feitosa de Castro, João Lucas Lima Calandrini de Azevedo, Ronaldo Moraes Preto, Miriam Leandro Dorta, Daniela Espíndola Antunes, Simone Gonçalves Fonseca   +7 more
wiley   +1 more source

Obesity Promotes Renal Inflammation and Fibrosis Independent of Sex in SS Leptin Receptor Mutant (SS^LepR) Rats. [PDF]

Biomedicines
Saad KM, Gad MS, Tang J, Capehart K, Abdelsayed R, Williams JM, Elmarakby AA.   +6 more
europepmc   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Protective effects of swimming exercise on experimental rheumatoid arthritis in rats through modulation of leptin receptor expression and inflammation. [PDF]

Turk J Phys Med Rehabil
Yavaş Durasıllı T, Zateri C, Yüksel P, Şaker D, Demir U, Karatağ O, Sencar L, Ülker Çakır D, Edremitlioğlu M.   +8 more
europepmc   +1 more source