Results 211 to 220 of about 75,788 (264)

Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia. [PDF]

Cell Discov
Yuan XS, Xiang Z, Jiang JB, Yuan F, Zhang MT, Zhang KY, Chen ZY, Qu WM, Li WS, Huang ZL.   +9 more
europepmc   +1 more source

Effect of <i>Aeromonas hydrophila</i> infection on leptin receptor overlapping transcript expression in <i>Rana amurensis</i>. [PDF]

Anim Biotechnol
Sun Y, Wu T, Chen Z, Ren H, Liu Y, Liu P, Zhao W.   +6 more
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first-in-human phase I study. [PDF]

Clin Transl Sci
Gewitz A, Mendell J, Wang Y, Harris C, Olenchock BA, Podgrabinska S, Zheng W, Zhao A, Pan H, Vanhoutte F, Davis JD.   +10 more
europepmc   +1 more source

Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice. [PDF]

Elife
Sáenz de Miera C, Bellefontaine N, Allen SJ, Myers MG, Elias CF.   +4 more
europepmc   +1 more source

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The soluble leptin receptor

Best Practice and Research in Clinical Endocrinology and Metabolism, 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms. The amount of functionally active OB-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sOB-R), is the main binding protein for leptin in human blood
Michael Schaab, Juergen Kratzsch
exaly   +3 more sources

Localization of Leptin Binding Domain in the Leptin Receptor

Molecular Pharmacology, 1998
The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid sequence of the extracellular region of the cloned leptin receptor differs from that of many other cytokine receptors in that it contains two homologous segments representing potential ligand ...
R R Huang, J E Krause, T M Fong
exaly   +3 more sources

Atomistic mechanism of leptin and leptin-receptor association

Journal of Biomolecular Structure and Dynamics, 2022
The leptin-leptin receptor complex is at the very core of energy homeostasis and immune system regulation, among many other functions. In this work, we built homology models of leptin and the leptin binding domain (LBD) of the receptor from humans and mice.
Marisol López-Hidalgo, Luis A. Caro-Gómez, Rubí Romo-Rodríguez, Leonardo D. Herrera-Zuñiga, Maricruz Anaya-Reyes, Jorge L. Rosas-Trigueros, Claudia G. Benítez-Cardoza   +6 more
openaire   +2 more sources

Leptin and its receptors

Journal of Chemical Neuroanatomy, 2014
Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Nobuhiro, Wada, Satoshi, Hirako, Fumiko, Takenoya, Haruaki, Kageyama, Mai, Okabe, Seiji, Shioda   +5 more
openaire   +2 more sources