Results 231 to 240 of about 138,647 (310)

Setmelanotide in Bardet‐Biedl Syndrome: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith, Eric Sanfilippo, Lara Wine Lee   +2 more
wiley   +1 more source

Characterization of Leptin and Leptin Receptor Gene in the Siberian Sturgeon (<i>Acipenser baerii</i>): Molecular Cloning, Tissue Distribution, and Its Involvement in Feeding Regulation. [PDF]

Int J Mol Sci
Wu H, Li J, Jiang K, Li Y, Yu Z, Wang B, Zhou B, Zhang X, Tang N, Li Z.   +9 more
europepmc   +1 more source

Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice. [PDF]

Brain
Fernandes C, Forny-Germano L, Andrade MM, Lyra E Silva NM, Ramos-Lobo AM, Meireles F, Tovar-Moll F, Houzel JC, Donato J, De Felice FG.   +9 more
europepmc   +1 more source

Prime editing-mediated correction of the leptin receptor in muscle cells of db/db mice. [PDF]

Biotechnol J
Lee KE, Xu Y, Geng B, Kim J, Kellon N, He Z, Zhang Z, Li D, Gouchoe DA, Zhu H.   +9 more
europepmc   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice.

Endocrinology
Miles TK, Odle AK, Byrum SD, Lagasse AN, Haney AC, Ortega VG, Herdman AK, MacNicol MC, MacNicol AM, Childs GV.   +9 more
europepmc   +1 more source

Immune system benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by pulmonary and systemic inflammation. Inflammatory mediators show relationships with shortness of breath, exercise intolerance and health related quality of life. Pulmonary rehabilitation (PR), a comprehensive education and exercise training programme, is the
Asghar Abbasi, David Wang, William W. Stringer, Richard Casaburi, Harry B. Rossiter   +4 more
wiley   +1 more source

Hypomethylated leptin receptor reduces cerebral ischaemia-reperfusion injury by activating the JAK2/STAT3 signalling pathway. [PDF]

J Int Med Res
Wang X, Wang Z, Liu S, Feng Y, Zhang T, Wu Z, Huang J, Zhao W.   +7 more
europepmc   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Leptin Receptor Deficiency Impairs Lymph Node Development and Adaptive Immune Response. [PDF]

J Immunol
Cardani-Boulton A, Sung SJ, Petri WA, Hahn YS, Braciale TJ.   +4 more
europepmc   +1 more source