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Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice. [PDF]

Diabetol Metab Syndr
Tong D, Xiang J, Liu W, Sun F, Wang L, Mou A, Cao T, Zhou Q, You M, Liao Y, Gao P, Liu D, Lu Z, Zhu Z.   +13 more
europepmc   +1 more source

CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.

Am J Physiol Regul Integr Comp Physiol
Neyens DM, Brenner L, Calkins R, Winzenried ET, Ritter RC, Appleyard SM.   +5 more
europepmc   +1 more source

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Atomistic mechanism of leptin and leptin-receptor association

Journal of Biomolecular Structure and Dynamics, 2022
The leptin-leptin receptor complex is at the very core of energy homeostasis and immune system regulation, among many other functions. In this work, we built homology models of leptin and the leptin binding domain (LBD) of the receptor from humans and mice.
Marisol López-Hidalgo, Luis A. Caro-Gómez, Rubí Romo-Rodríguez, Leonardo D. Herrera-Zuñiga, Maricruz Anaya-Reyes, Jorge L. Rosas-Trigueros, Claudia G. Benítez-Cardoza   +6 more
openaire   +2 more sources

Leptin and leptin receptor-related monogenic obesity

Biochimie, 2012
The studies based on candidate genes and encoded proteins known to cause severe obesity in rodents, have shown that these genes also contribute to human early-onset obesity especially for those involved in the leptin pathway: the leptin (LEP) and leptin receptor (LEPR) genes.
Beatrice, Dubern, Karine, Clement
openaire   +2 more sources