Results 41 to 50 of about 11,910 (159)

Literature Review: Role of Neurosurgery in Leptomeningeal Carcinomatosis

Brazilian Neurosurgery, 2023
Introduction Leptomeningeal carcinomatosis results from metastatic neoplastic cells that reach the leptomeninges through the cerebrospinal fluid. The presentation of the disease is variable, making prognosis challenging.
Thaís Mitie Ogasawara, Thaís Yumi Kobayashi Batista, Rafael Rodrigues Pinheiro dos Santos, Ana Carla Mondek Rampazzo, Caroline Amane Pessoa Badaoui, Igor Ruan de Araújo Caetano, Jonathan Vinícius Martins, Maria Letícia Nogueira, José Ângelo Guarnieri, Carlos Alexandre Martins Zicarelli   +9 more
doaj   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

Leptomeningeal carcinomatosis, an emerging disease in internal medicine departments with a generally poor prognosis: two case reports

Italian Journal of Medicine
As a result of improved diagnostic methods and higher cancer patient survival rates, leptomeningeal carcinomatosis is being found in internal medicine departments more frequently.
Filomena Pietrantonio, Margherita Lordi, Fabio Vinci, Elena Alessi, Matteo Pascucci, Michela Delli Castelli, Antonio Vinci, Enrica Cipriano, Francesco Rosiello, Angela Ciamei   +9 more
doaj   +1 more source

Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination

Radiology Case Reports, 2018
Dysembryoplastic neuroepithelial tumors (DNETs) are typically benign World Health Organization (WHO) grade I tumors of the cortical or deep gray matter with a favorable prognosis.
Amy Farkas, MD, David Joyner, MD, Ali G. Saad, MD, Mark Anderson, MD, Majid Khan, MD   +4 more
doaj   +1 more source

Spinal Cord Sarcoidosis Treated With Infliximab

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Isolated spinal cord lesion could be misinterpreted as a demyelinating disease. The diagnosis of sarcoidosis should be in the differential when other indices for a demyelinating disorder are absent. An inadequate response to intravenous steroid therapy should not rule out spinal sarcoidosis as this report confirms the response to intravenous ...
Hussein Moussa, Roula Hourani Rizk, Nina S. Shabb, Nabil El Ayoubi, Raja Sawaya   +4 more
wiley   +1 more source

A case report of prostate cancer with leptomeningeal metastasis

Cancer Reports, 2022
Background Prostate cancer is the most prevalent cancer in men. However, leptomeningeal involvement by prostate carcinoma is a rare event. Case Here, we report a 69‐year‐old patient with castration‐resistant metastatic prostate cancer who presented with ...
Mansoureh Dehghani, Babak PeyroShabany, Ramin Shahraini, Danial Fazilat‐Panah, Fateme Hashemi, James S. Welsh, Seyed Alireza Javadinia   +6 more
doaj   +1 more source

Efficacy and Safety of Intraventricular Thiotepa in Combination With Methotrexate for Leptomeningeal Metastasis From Breast Cancer (NJMU‐BC04): A Single‐Arm Phase II Study

MedComm, Volume 7, Issue 9, September 2026.
Leptomeningeal metastasis (LM), an uncommon yet highly fatal condition, involves malignant tumor infiltration of the meninges resulting in progressive neurological deterioration and severe quality‐of‐life impairment. LM remains largely refractory to treatment and lacks standardized treatment consensus, with a low intracranial objective response rate ...
Wenbin Zhou, Mengyao Zha, Hehui Fang, Kai Cao, Jiaqi Yong, Yue Sun, Yuan Yuan, Jian Zhang, Shencun Fang, Qiang Ding, Wei Li   +10 more
wiley   +1 more source

Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 9, September 2026.
ABSTRACT Leptomeningeal metastasis (LM) is a rare complication of cervical cancer associated with a poor prognosis. We report a 61‐year‐old woman with stage IVB cervical squamous cell carcinoma who developed acute headache and diplopia during systemic chemotherapy.
Chery Ahn, Haein Seo, Dongmin Jo, Byeol Han, Eunmi Choi, Sewon Kim, Seo Woo Chung, Ok‐Ju Kang   +7 more
wiley   +1 more source

Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature

Case Reports in Oncological Medicine, 2013
We report the case of a 65-year-old woman, diagnosed with a breast cancer human epidermal growth factor receptor (HER2) previously negative, who developed leptomeningeal carcinomatosis and was treated with intrathecal (IT) trastuzumab (TST).
Cristina Dumitrescu, Dominique Lossignol
doaj   +1 more source

Lorlatinib in pretreated ALK- or ROS1-positive lung cancer and impact of TP53 co-mutations: results from the German early access program

Therapeutic Advances in Medical Oncology, 2021
Introduction: We report on the results of the German early access program (EAP) with the third-generation ALK- and ROS1-inhibitor lorlatinib. Patients and Methods: Patients with documented treatment failure of all approved ALK/ROS1-specific therapies or ...
Nikolaj Frost, Petros Christopoulos, Diego Kauffmann-Guerrero, Jan Stratmann, Richard Riedel, Monica Schaefer, Jürgen Alt, Sylvia Gütz, Daniel C. Christoph, Eckart Laack, Martin Faehling, Richard Fischer, Klaus Fenchel, Sebastian Haen, Lukas Heukamp, Christian Schulz, Frank Griesinger   +16 more
doaj   +1 more source