Results 51 to 60 of about 5,255,382 (240)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid [PDF]

, 2022
In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells.
Pablo Juanes-Velasco, Peter Nilsson, Lorenzo-Gil, Héctor, Nilsson, Peter,, Juanes-Velasco, Pablo, Landeira-Vinuela, Alicia,, García-Valiente, R., Rodrigo García-Valiente, Lécrevisse, Quentin, Fuentes, Manuel, Bareke, Halin,, Landeira-Viñuela, Alicia, Alberto Orfao, Gongora, Rafael,, Pedreira, Carlos Eduardo,, Sanchez-Santos, Jose Manuel,, Jose Manuel Sanchez-Santos, Jara-Acevedo, Ricardo, Bareke, Halin, Halin Bareke, Carlos Eduardo Pedreira, Orfao, Alberto, Ricardo Jara-Acevedo, Alicia Landeira-Viñuela, Carabias-Sanchez, Javier,, Manuel Fuentes, Pin, Elisa,, Pedreira, C. E., Jara-Acevedo, Ricardo,, Galicia, N., Elisa Pin, Nilsson, Peter, Lecrevisse, Quentin,, Javier Carabias-Sánchez, Rafael Gongora, Fuentes, Manuel,, Norma Galicia, Lorenzo-Gil, Hector,, Quentin Lecrevisse, Garcia-Valiente, Rodrigo,, Galicia, Norma,, Orfao, Alberto,, Héctor Lorenzo-Gil, Pin, Elisa, Juanes-Velasco, Pablo,, Carabias-Sánchez, Javier, Góngora, Rafael, Sánchez-Santos, José Manuel   +47 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Population-Based Real-World Outcomes of Post-Operative Adjuvant Brain Cavity Radiotherapy Versus Observation

Current Oncology
To evaluate the factors influencing the outcomes of patients who underwent surgical resection of brain metastasis followed by either surveillance or post-operative stereotactic radiosurgery/fractionated radiotherapy (SRS/SFRT), a retrospective multi ...
Zhang Hao (Jim) Li, Linden Lechner, Jennifer Wang, Nan Hui (Susan) Yao, Andrew Lee, Serge Makarenko, Mostafa Fatehi, Herve H. F. Choi, Ermias Gete, Fred Hsu, Waseem Sharieff, Shrinivas Rathod, Hannah Carolan, Jessica Chan, Roy Ma, Alan Nichol, Thi Nghiem, Justin Oh   +17 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Leptomeningeal Metastasis with Perivascular Invasion in a Case of Breast Carcinoma: A Radiological Perspective

Journal of Medical Sciences
Leptomeningeal metastasis (LM) is an under-recognized radiological entity that often mimics classic leptomeningeal disease but presents with perivascular invasion.
Rekha Gupta, Chandrika Sachar, Sanjeev Jindal, Ritika Gupta   +3 more
doaj   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

A review on intrathecal administration of medications for leptomeningeal metastases in solid tumors

Frontiers in Pharmacology
Leptomeningeal disease (LMD) is a particular mode of central metastasis in malignant tumors. It occurs when tumor cells infiltrate the subarachnoid space and cerebrospinal fluid (CSF), spreading throughout the central nervous system (CNS).
Xuemei Wang, Chi Yao, Li Quan, Junxiang Zhou   +3 more
doaj   +1 more source

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

Management and survival of patients with leptomeningeal disease from breast cancer: a case series

, 2017
Leptomeningeal disease (LMD) in breast cancer is a rare complication and often portends a poor prognosis. There is a lack of randomized data guiding treatment decisions and no accepted standard of care in the management of LMD.
Jasotha Sanmugarajah, Roberts, Kate, Ghimire, Ram, Kate Roberts, Sanmugarajah, Jasotha, Sophie Feng, Ram Ghimire, Feng, Sophie   +7 more
core   +1 more source